Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)

Kumiko Horiuchi; Sumiko Shiota; Tsutomu Hatano; Takashi Yoshida; Teruo Kuroda; Tomofusa Tsuchiya

doi:10.1248/bpb.30.1147

Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)

Kumiko Horiuchi, Sumiko Shiota, Tsutomu Hatano, Takashi Yoshida, Teruo Kuroda, Tomofusa Tsuchiya

Research output: Contribution to journal › Article

130 Citations (Scopus)

Abstract

An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.

Original language	English
Pages (from-to)	1147-1149
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	6
DOIs	https://doi.org/10.1248/bpb.30.1147
Publication status	Published - Jun 2007
Externally published	Yes

Keywords

Bactericidal activity
Oleanolic acid
Sage
Ursolic acid
Vancomycin-resistant enterococci (VRE)

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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Horiuchi, K., Shiota, S., Hatano, T., Yoshida, T., Kuroda, T., & Tsuchiya, T. (2007). Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). Biological and Pharmaceutical Bulletin, 30(6), 1147-1149. https://doi.org/10.1248/bpb.30.1147

Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). / Horiuchi, Kumiko; Shiota, Sumiko; Hatano, Tsutomu; Yoshida, Takashi; Kuroda, Teruo; Tsuchiya, Tomofusa.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 6, 06.2007, p. 1147-1149.

Research output: Contribution to journal › Article

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abstract = "An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.",

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