Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)

Kumiko Horiuchi; Sumiko Shiota; Tsutomu Hatano; Takashi Yoshida; Teruo Kuroda; Tomofusa Tsuchiya

doi:10.1248/bpb.30.1147

Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)

Kumiko Horiuchi, Sumiko Shiota, Tsutomu Hatano, Takashi Yoshida, Teruo Kuroda, Tomofusa Tsuchiya

Research output: Contribution to journal › Article › peer-review

165 Citations (Scopus)

Abstract

An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.

Original language	English
Pages (from-to)	1147-1149
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	6
DOIs	https://doi.org/10.1248/bpb.30.1147
Publication status	Published - Jun 2007
Externally published	Yes

Keywords

Bactericidal activity
Oleanolic acid
Sage
Ursolic acid
Vancomycin-resistant enterococci (VRE)

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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title = "Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)",

abstract = "An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.",

keywords = "Bactericidal activity, Oleanolic acid, Sage, Ursolic acid, Vancomycin-resistant enterococci (VRE)",

author = "Kumiko Horiuchi and Sumiko Shiota and Tsutomu Hatano and Takashi Yoshida and Teruo Kuroda and Tomofusa Tsuchiya",

year = "2007",

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AU - Horiuchi, Kumiko

AU - Shiota, Sumiko

AU - Hatano, Tsutomu

AU - Yoshida, Takashi

AU - Kuroda, Teruo

AU - Tsuchiya, Tomofusa

PY - 2007/6

Y1 - 2007/6

N2 - An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.

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KW - Bactericidal activity

KW - Oleanolic acid

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KW - Ursolic acid

KW - Vancomycin-resistant enterococci (VRE)

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Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)

Abstract

Keywords

ASJC Scopus subject areas

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