Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE)

Kumiko Horiuchi, Sumiko Shiota, Tsutomu Hatano, Takashi Yoshida, Teruo Kuroda, Tomofusa Tsuchiya

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128 Citations (Scopus)


An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.

Original languageEnglish
Pages (from-to)1147-1149
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - Jun 1 2007
Externally publishedYes



  • Bactericidal activity
  • Oleanolic acid
  • Sage
  • Ursolic acid
  • Vancomycin-resistant enterococci (VRE)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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