Antimalarial and cytotoxic activities of bicyclo[6.4.0]dodecenones

H. Fujishima, H. Takeshita, M. Toyota, Hye-Sook Kim, Y. Wataya, M. Tanaka, T. Sasaki, M. Ihara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Biological evaluations of bicyclo[6.4.0]dodecenone derivatives on antimalarial activity in vitro against Plasmodium falciparum and cytotoxicity against human KB cells were made. (±)-(1R*4S*7R*,8S*)-4-tert- Butyldimethylsiloxy-5,5-dimethyl-1-methyl-9-methylene-7- phenylsulfonylbicyclo[6.4.0]dodec-2,11-dien-10-one (15) exhibited potent antimalarial activity, whereas (±)-(1R*7*8*)-1-methyl-9-methylene-7- phenylsulfonylbicyclo[6.4.0]dodec-2,11-dien-10-one (14) showed significant cytotoxic activity in human KB cells. Both 14 and 15 possess, as a structural character, the exo-methylene moiety in their 6-membered ring of the 8-6 fused ring system.

Original languageEnglish
Pages (from-to)572-575
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume49
Issue number5
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

KB Cells
Antimalarials
Plasmodium falciparum
Cytotoxicity
Human Activities
Derivatives
In Vitro Techniques

Keywords

  • Antimalarial activity
  • Bicyclo[6.4.0]dodecenone
  • Cytotoxicity

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Fujishima, H., Takeshita, H., Toyota, M., Kim, H-S., Wataya, Y., Tanaka, M., ... Ihara, M. (2001). Antimalarial and cytotoxic activities of bicyclo[6.4.0]dodecenones. Chemical and Pharmaceutical Bulletin, 49(5), 572-575. https://doi.org/10.1248/cpb.49.572

Antimalarial and cytotoxic activities of bicyclo[6.4.0]dodecenones. / Fujishima, H.; Takeshita, H.; Toyota, M.; Kim, Hye-Sook; Wataya, Y.; Tanaka, M.; Sasaki, T.; Ihara, M.

In: Chemical and Pharmaceutical Bulletin, Vol. 49, No. 5, 2001, p. 572-575.

Research output: Contribution to journalArticle

Fujishima, H, Takeshita, H, Toyota, M, Kim, H-S, Wataya, Y, Tanaka, M, Sasaki, T & Ihara, M 2001, 'Antimalarial and cytotoxic activities of bicyclo[6.4.0]dodecenones', Chemical and Pharmaceutical Bulletin, vol. 49, no. 5, pp. 572-575. https://doi.org/10.1248/cpb.49.572
Fujishima, H. ; Takeshita, H. ; Toyota, M. ; Kim, Hye-Sook ; Wataya, Y. ; Tanaka, M. ; Sasaki, T. ; Ihara, M. / Antimalarial and cytotoxic activities of bicyclo[6.4.0]dodecenones. In: Chemical and Pharmaceutical Bulletin. 2001 ; Vol. 49, No. 5. pp. 572-575.
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