Antimalarial activity of yingzhaosu A analogues

Hye Sook Kim; Khurshida Begum; Naoki Ogura; Yusuke Wataya; Takahiro Tokuyasu; Araki Masuyama; Masatomo Nojima; Kevin J. McCullough

doi:10.1021/jm020208q

Antimalarial activity of yingzhaosu A analogues

Hye Sook Kim, Khurshida Begum, Naoki Ogura, Yusuke Wataya, Takahiro Tokuyasu, Araki Masuyama, Masatomo Nojima, Kevin J. McCullough

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.

Original language	English
Pages (from-to)	4732-4736
Number of pages	5
Journal	Journal of medicinal chemistry
Volume	45
Issue number	21
DOIs	https://doi.org/10.1021/jm020208q
Publication status	Published - Oct 10 2002

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm020208q

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author = "Kim, {Hye Sook} and Khurshida Begum and Naoki Ogura and Yusuke Wataya and Takahiro Tokuyasu and Araki Masuyama and Masatomo Nojima and McCullough, {Kevin J.}",

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AU - Kim, Hye Sook

AU - Begum, Khurshida

AU - Ogura, Naoki

AU - Wataya, Yusuke

AU - Tokuyasu, Takahiro

AU - Masuyama, Araki

AU - Nojima, Masatomo

AU - McCullough, Kevin J.

PY - 2002/10/10

Y1 - 2002/10/10

N2 - Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.

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Antimalarial activity of yingzhaosu A analogues

Abstract

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