Antimalarial activity of yingzhaosu A analogues

Hye Sook Kim, Khurshida Begum, Naoki Ogura, Yusuke Wataya, Takahiro Tokuyasu, Araki Masuyama, Masatomo Nojima, Kevin J. McCullough

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.

Original languageEnglish
Pages (from-to)4732-4736
Number of pages5
JournalJournal of medicinal chemistry
Volume45
Issue number21
DOIs
Publication statusPublished - Oct 10 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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  • Cite this

    Kim, H. S., Begum, K., Ogura, N., Wataya, Y., Tokuyasu, T., Masuyama, A., Nojima, M., & McCullough, K. J. (2002). Antimalarial activity of yingzhaosu A analogues. Journal of medicinal chemistry, 45(21), 4732-4736. https://doi.org/10.1021/jm020208q