Abstract
Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 4732-4736 |
| Number of pages | 5 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 45 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - Oct 10 2002 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Antimalarial activity of yingzhaosu A analogues. / Kim, Hye-Sook; Begum, Khurshida; Ogura, Naoki; Wataya, Yusuke; Tokuyasu, Takahiro; Masuyama, Araki; Nojima, Masatomo; McCullough, Kevin J.
In: Journal of Medicinal Chemistry, Vol. 45, No. 21, 10.10.2002, p. 4732-4736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antimalarial activity of yingzhaosu A analogues
AU - Kim, Hye-Sook
AU - Begum, Khurshida
AU - Ogura, Naoki
AU - Wataya, Yusuke
AU - Tokuyasu, Takahiro
AU - Masuyama, Araki
AU - Nojima, Masatomo
AU - McCullough, Kevin J.
PY - 2002/10/10
Y1 - 2002/10/10
N2 - Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.
AB - Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0037057574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037057574&partnerID=8YFLogxK
U2 - 10.1021/jm020208q
DO - 10.1021/jm020208q
M3 - Article
VL - 45
SP - 4732
EP - 4736
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 21
ER -