Abstract
Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.
Original language | English |
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Pages (from-to) | 4732-4736 |
Number of pages | 5 |
Journal | Journal of medicinal chemistry |
Volume | 45 |
Issue number | 21 |
DOIs | |
Publication status | Published - Oct 10 2002 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery