Antimalarial activity of yingzhaosu A analogues

Hye-Sook Kim, Khurshida Begum, Naoki Ogura, Yusuke Wataya, Takahiro Tokuyasu, Araki Masuyama, Masatomo Nojima, Kevin J. McCullough

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.

Original languageEnglish
Pages (from-to)4732-4736
Number of pages5
JournalJournal of Medicinal Chemistry
Volume45
Issue number21
DOIs
Publication statusPublished - Oct 10 2002

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Peroxides
Antimalarials
Cyclic Ethers
Cyclization
Hydrogen Peroxide
Ions
yingzhaosu A
In Vitro Techniques

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Kim, H-S., Begum, K., Ogura, N., Wataya, Y., Tokuyasu, T., Masuyama, A., ... McCullough, K. J. (2002). Antimalarial activity of yingzhaosu A analogues. Journal of Medicinal Chemistry, 45(21), 4732-4736. https://doi.org/10.1021/jm020208q

Antimalarial activity of yingzhaosu A analogues. / Kim, Hye-Sook; Begum, Khurshida; Ogura, Naoki; Wataya, Yusuke; Tokuyasu, Takahiro; Masuyama, Araki; Nojima, Masatomo; McCullough, Kevin J.

In: Journal of Medicinal Chemistry, Vol. 45, No. 21, 10.10.2002, p. 4732-4736.

Research output: Contribution to journalArticle

Kim, H-S, Begum, K, Ogura, N, Wataya, Y, Tokuyasu, T, Masuyama, A, Nojima, M & McCullough, KJ 2002, 'Antimalarial activity of yingzhaosu A analogues', Journal of Medicinal Chemistry, vol. 45, no. 21, pp. 4732-4736. https://doi.org/10.1021/jm020208q
Kim H-S, Begum K, Ogura N, Wataya Y, Tokuyasu T, Masuyama A et al. Antimalarial activity of yingzhaosu A analogues. Journal of Medicinal Chemistry. 2002 Oct 10;45(21):4732-4736. https://doi.org/10.1021/jm020208q
Kim, Hye-Sook ; Begum, Khurshida ; Ogura, Naoki ; Wataya, Yusuke ; Tokuyasu, Takahiro ; Masuyama, Araki ; Nojima, Masatomo ; McCullough, Kevin J. / Antimalarial activity of yingzhaosu A analogues. In: Journal of Medicinal Chemistry. 2002 ; Vol. 45, No. 21. pp. 4732-4736.
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