Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens

Youn Chul Kim, Hye Sook Kim, Yusuke Wataya, Dong Hwan Sohn, Tai Hyun Kang, Myung Soo Kim, Yong Man Kim, Geon Mok Lee, Jong Duk Chang, Hyun Park

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33 Citations (Scopus)

Abstract

Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC50 values of 2.4×10-6, 2.6×10-6, and 2.1×10 -6M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.

Original languageEnglish
Pages (from-to)748-750
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume27
Issue number5
DOIs
Publication statusPublished - May 1 2004

Keywords

  • Antimalarial
  • Lavandulyl flavanone
  • Plasmodium falciparum
  • Sophora flavescens

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Kim, Y. C., Kim, H. S., Wataya, Y., Sohn, D. H., Kang, T. H., Kim, M. S., Kim, Y. M., Lee, G. M., Chang, J. D., & Park, H. (2004). Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens. Biological and Pharmaceutical Bulletin, 27(5), 748-750. https://doi.org/10.1248/bpb.27.748