Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Hiroaki Miyaoka, Masako Shimomura, Haruko Kimura, Yasuji Yamada, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

Original languageEnglish
Pages (from-to)13467-13474
Number of pages8
JournalTetrahedron
Volume54
Issue number44
DOIs
Publication statusPublished - Oct 29 1998

Keywords

  • Antimalarial compounds
  • Marine metabolites
  • Natural products
  • Terpenes and terpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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