Abstract
Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.
| Original language | English |
|---|---|
| Pages (from-to) | 13467-13474 |
| Number of pages | 8 |
| Journal | Tetrahedron |
| Volume | 54 |
| Issue number | 44 |
| DOIs | |
| Publication status | Published - Oct 29 1998 |
Keywords
- Antimalarial compounds
- Marine metabolites
- Natural products
- Terpenes and terpenoids
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Miyaoka, H., Shimomura, M., Kimura, H., Yamada, Y., Kim, H. S., & Wataya, Y. (1998). Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp. Tetrahedron, 54(44), 13467-13474. https://doi.org/10.1016/S0040-4020(98)00818-7