Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Hiroaki Miyaoka, Masako Shimomura, Haruko Kimura, Yasuji Yamada, Hye-Sook Kim, Yusuke Wataya

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

Original languageEnglish
Pages (from-to)13467-13474
Number of pages8
JournalTetrahedron
Volume54
Issue number44
DOIs
Publication statusPublished - Oct 29 1998

Fingerprint

Diterpenes
Antimalarials
Porifera
kalihinol A
kalihinane
kalihinol Y
In Vitro Techniques

Keywords

  • Antimalarial compounds
  • Marine metabolites
  • Natural products
  • Terpenes and terpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp. / Miyaoka, Hiroaki; Shimomura, Masako; Kimura, Haruko; Yamada, Yasuji; Kim, Hye-Sook; Wataya, Yusuke.

In: Tetrahedron, Vol. 54, No. 44, 29.10.1998, p. 13467-13474.

Research output: Contribution to journalArticle

Miyaoka, Hiroaki ; Shimomura, Masako ; Kimura, Haruko ; Yamada, Yasuji ; Kim, Hye-Sook ; Wataya, Yusuke. / Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp. In: Tetrahedron. 1998 ; Vol. 54, No. 44. pp. 13467-13474.
@article{f255a0d9e88b45ff8a6231f378c44b42,
title = "Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.",
abstract = "Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.",
keywords = "Antimalarial compounds, Marine metabolites, Natural products, Terpenes and terpenoids",
author = "Hiroaki Miyaoka and Masako Shimomura and Haruko Kimura and Yasuji Yamada and Hye-Sook Kim and Yusuke Wataya",
year = "1998",
month = "10",
day = "29",
doi = "10.1016/S0040-4020(98)00818-7",
language = "English",
volume = "54",
pages = "13467--13474",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "44",

}

TY - JOUR

T1 - Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

AU - Miyaoka, Hiroaki

AU - Shimomura, Masako

AU - Kimura, Haruko

AU - Yamada, Yasuji

AU - Kim, Hye-Sook

AU - Wataya, Yusuke

PY - 1998/10/29

Y1 - 1998/10/29

N2 - Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

AB - Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

KW - Antimalarial compounds

KW - Marine metabolites

KW - Natural products

KW - Terpenes and terpenoids

UR - http://www.scopus.com/inward/record.url?scp=0032578719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032578719&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(98)00818-7

DO - 10.1016/S0040-4020(98)00818-7

M3 - Article

AN - SCOPUS:0032578719

VL - 54

SP - 13467

EP - 13474

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 44

ER -