Abstract
Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.
| Original language | English |
|---|---|
| Pages (from-to) | 13467-13474 |
| Number of pages | 8 |
| Journal | Tetrahedron |
| Volume | 54 |
| Issue number | 44 |
| DOIs | |
| Publication status | Published - Oct 29 1998 |
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Keywords
- Antimalarial compounds
- Marine metabolites
- Natural products
- Terpenes and terpenoids
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp. / Miyaoka, Hiroaki; Shimomura, Masako; Kimura, Haruko; Yamada, Yasuji; Kim, Hye-Sook; Wataya, Yusuke.
In: Tetrahedron, Vol. 54, No. 44, 29.10.1998, p. 13467-13474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.
AU - Miyaoka, Hiroaki
AU - Shimomura, Masako
AU - Kimura, Haruko
AU - Yamada, Yasuji
AU - Kim, Hye-Sook
AU - Wataya, Yusuke
PY - 1998/10/29
Y1 - 1998/10/29
N2 - Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.
AB - Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.
KW - Antimalarial compounds
KW - Marine metabolites
KW - Natural products
KW - Terpenes and terpenoids
UR - http://www.scopus.com/inward/record.url?scp=0032578719&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032578719&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(98)00818-7
DO - 10.1016/S0040-4020(98)00818-7
M3 - Article
VL - 54
SP - 13467
EP - 13474
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 44
ER -