Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Hiroaki Miyaoka; Masako Shimomura; Haruko Kimura; Yasuji Yamada; Hye Sook Kim; Yusuke Wataya

doi:10.1016/S0040-4020(98)00818-7

Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Hiroaki Miyaoka, Masako Shimomura, Haruko Kimura, Yasuji Yamada, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journal › Article

76 Citations (Scopus)

Abstract

Three new kalihinane diterpenoids Δ⁹-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

Original language	English
Pages (from-to)	13467-13474
Number of pages	8
Journal	Tetrahedron
Volume	54
Issue number	44
DOIs	https://doi.org/10.1016/S0040-4020(98)00818-7
Publication status	Published - Oct 29 1998

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Keywords

Antimalarial compounds
Marine metabolites
Natural products
Terpenes and terpenoids

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Miyaoka, H., Shimomura, M., Kimura, H., Yamada, Y., Kim, H. S., & Wataya, Y. (1998). Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp. Tetrahedron, 54(44), 13467-13474. https://doi.org/10.1016/S0040-4020(98)00818-7

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abstract = "Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.",

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AU - Yamada, Yasuji

AU - Kim, Hye Sook

AU - Wataya, Yusuke

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10.1016/S0040-4020(98)00818-7