Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Hiroaki Miyaoka; Masako Shimomura; Haruko Kimura; Yasuji Yamada; Hye Sook Kim; Yusuke Wataya

doi:10.1016/S0040-4020(98)00818-7

Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Hiroaki Miyaoka, Masako Shimomura, Haruko Kimura, Yasuji Yamada, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Three new kalihinane diterpenoids Δ⁹-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

Original language	English
Pages (from-to)	13467-13474
Number of pages	8
Journal	Tetrahedron
Volume	54
Issue number	44
DOIs	https://doi.org/10.1016/S0040-4020(98)00818-7
Publication status	Published - Oct 29 1998

Keywords

Antimalarial compounds
Marine metabolites
Natural products
Terpenes and terpenoids

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4020(98)00818-7

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title = "Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.",

abstract = "Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.",

keywords = "Antimalarial compounds, Marine metabolites, Natural products, Terpenes and terpenoids",

author = "Hiroaki Miyaoka and Masako Shimomura and Haruko Kimura and Yasuji Yamada and Kim, {Hye Sook} and Yusuke Wataya",

note = "Funding Information: Acknowledgments: This work was supporteidn partb y a Grant-in-Aidfso r ScientificR esearcho n PriorityA reas( GrantN o. 10166224a nd0 8281105f)r omthe Ministryo f,E ducationS, cienceC, ulturea nd Sports.",

year = "1998",

month = oct,

day = "29",

doi = "10.1016/S0040-4020(98)00818-7",

language = "English",

volume = "54",

pages = "13467--13474",

journal = "Tetrahedron",

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number = "44",

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TY - JOUR

T1 - Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

AU - Miyaoka, Hiroaki

AU - Shimomura, Masako

AU - Kimura, Haruko

AU - Yamada, Yasuji

AU - Kim, Hye Sook

AU - Wataya, Yusuke

N1 - Funding Information: Acknowledgments: This work was supporteidn partb y a Grant-in-Aidfso r ScientificR esearcho n PriorityA reas( GrantN o. 10166224a nd0 8281105f)r omthe Ministryo f,E ducationS, cienceC, ulturea nd Sports.

PY - 1998/10/29

Y1 - 1998/10/29

N2 - Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

AB - Three new kalihinane diterpenoids Δ9-kalihinol Y (1), 10-epikalihinol I (2) and 5,10-bisisothiocyanatokalihinol G (3) were isolated in the present study along with previously detected kalihinane diterpenoids kalihinol A (4), kalihinene (5) and 6-hydroxykalihinene (6) from the Okinawan marine sponge, Acanthella sp. Kalihinol A (4) was noted to possess remarkable in vitro antimalarial activity.

KW - Antimalarial compounds

KW - Marine metabolites

KW - Natural products

KW - Terpenes and terpenoids

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U2 - 10.1016/S0040-4020(98)00818-7

DO - 10.1016/S0040-4020(98)00818-7

M3 - Article

AN - SCOPUS:0032578719

VL - 54

SP - 13467

EP - 13474

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 44

ER -

Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthella sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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