Antimalarial activity of herbal extracts used in traditional medicine in Korea

Hyun Park, Myung Soo Kim, Byung Hun Jeon, Tae Kyun Kim, Yong Man Kim, Joohong Ahnn, Dong Yeul Kwon, Yoshiaki Takaya, Yusuke Wataya, Hye Sook Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum. The EC50 values for the herbal extracts were in the range 1.4-8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC50=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity=1). In contrast, Kalopanax pictus showed antimalarial activity (EC50=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.

Original languageEnglish
Pages (from-to)1623-1624
Number of pages2
JournalBiological and Pharmaceutical Bulletin
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 1 2003

Keywords

  • Antimalarial drug
  • Coptis japonica
  • Drug-resistant malaria
  • Kalopanax pictus
  • Plasmodium falciparum
  • Traditional Korean medicine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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  • Cite this

    Park, H., Kim, M. S., Jeon, B. H., Kim, T. K., Kim, Y. M., Ahnn, J., Kwon, D. Y., Takaya, Y., Wataya, Y., & Kim, H. S. (2003). Antimalarial activity of herbal extracts used in traditional medicine in Korea. Biological and Pharmaceutical Bulletin, 26(11), 1623-1624. https://doi.org/10.1248/bpb.26.1623