Antimalarial activity of herbal extracts used in traditional medicine in Korea

Hyun Park; Myung Soo Kim; Byung Hun Jeon; Tae Kyun Kim; Yong Man Kim; Joohong Ahnn; Dong Yeul Kwon; Yoshiaki Takaya; Yusuke Wataya; Hye Sook Kim

doi:10.1248/bpb.26.1623

Antimalarial activity of herbal extracts used in traditional medicine in Korea

Hyun Park, Myung Soo Kim, Byung Hun Jeon, Tae Kyun Kim, Yong Man Kim, Joohong Ahnn, Dong Yeul Kwon, Yoshiaki Takaya, Yusuke Wataya, Hye Sook Kim

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum. The EC₅₀ values for the herbal extracts were in the range 1.4-8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC₅₀=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity=1). In contrast, Kalopanax pictus showed antimalarial activity (EC₅₀=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.

Original language	English
Pages (from-to)	1623-1624
Number of pages	2
Journal	Biological and Pharmaceutical Bulletin
Volume	26
Issue number	11
DOIs	https://doi.org/10.1248/bpb.26.1623
Publication status	Published - Nov 2003

Keywords

Antimalarial drug
Coptis japonica
Drug-resistant malaria
Kalopanax pictus
Plasmodium falciparum
Traditional Korean medicine

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/bpb.26.1623

Cite this

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title = "Antimalarial activity of herbal extracts used in traditional medicine in Korea",

abstract = "Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum. The EC50 values for the herbal extracts were in the range 1.4-8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC50=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity=1). In contrast, Kalopanax pictus showed antimalarial activity (EC50=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.",

keywords = "Antimalarial drug, Coptis japonica, Drug-resistant malaria, Kalopanax pictus, Plasmodium falciparum, Traditional Korean medicine",

author = "Hyun Park and Kim, {Myung Soo} and Jeon, {Byung Hun} and Kim, {Tae Kyun} and Kim, {Yong Man} and Joohong Ahnn and Kwon, {Dong Yeul} and Yoshiaki Takaya and Yusuke Wataya and Kim, {Hye Sook}",

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language = "English",

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T1 - Antimalarial activity of herbal extracts used in traditional medicine in Korea

AU - Park, Hyun

AU - Kim, Myung Soo

AU - Jeon, Byung Hun

AU - Kim, Tae Kyun

AU - Kim, Yong Man

AU - Ahnn, Joohong

AU - Kwon, Dong Yeul

AU - Takaya, Yoshiaki

AU - Wataya, Yusuke

AU - Kim, Hye Sook

PY - 2003/11

Y1 - 2003/11

N2 - Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum. The EC50 values for the herbal extracts were in the range 1.4-8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC50=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity=1). In contrast, Kalopanax pictus showed antimalarial activity (EC50=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.

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KW - Antimalarial drug

KW - Coptis japonica

KW - Drug-resistant malaria

KW - Kalopanax pictus

KW - Plasmodium falciparum

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Antimalarial activity of herbal extracts used in traditional medicine in Korea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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