Antimalarial activity of herbal extracts used in traditional medicine in Korea

Hyun Park; Myung Soo Kim; Byung Hun Jeon; Tae Kyun Kim; Yong Man Kim; Joohong Ahnn; Dong Yeul Kwon; Yoshiaki Takaya; Yusuke Wataya; Hye Sook Kim

doi:10.1248/bpb.26.1623

Antimalarial activity of herbal extracts used in traditional medicine in Korea

Hyun Park, Myung Soo Kim, Byung Hun Jeon, Tae Kyun Kim, Yong Man Kim, Joohong Ahnn, Dong Yeul Kwon, Yoshiaki Takaya, Yusuke Wataya, Hye Sook Kim

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum. The EC₅₀ values for the herbal extracts were in the range 1.4-8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC₅₀=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity=1). In contrast, Kalopanax pictus showed antimalarial activity (EC₅₀=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.

Original language	English
Pages (from-to)	1623-1624
Number of pages	2
Journal	Biological and Pharmaceutical Bulletin
Volume	26
Issue number	11
DOIs	https://doi.org/10.1248/bpb.26.1623
Publication status	Published - Nov 2003

Keywords

Antimalarial drug
Coptis japonica
Drug-resistant malaria
Kalopanax pictus
Plasmodium falciparum
Traditional Korean medicine

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/bpb.26.1623

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Antimalarial activity of herbal extracts used in traditional medicine in Korea. / Park, Hyun; Kim, Myung Soo; Jeon, Byung Hun; Kim, Tae Kyun; Kim, Yong Man; Ahnn, Joohong; Kwon, Dong Yeul; Takaya, Yoshiaki; Wataya, Yusuke; Kim, Hye Sook.

In: Biological and Pharmaceutical Bulletin, Vol. 26, No. 11, 11.2003, p. 1623-1624.

Research output: Contribution to journal › Article › peer-review

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