Abstract
Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum. The EC50 values for the herbal extracts were in the range 1.4-8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC50=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity=1). In contrast, Kalopanax pictus showed antimalarial activity (EC50=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.
Original language | English |
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Pages (from-to) | 1623-1624 |
Number of pages | 2 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 26 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2003 |
Keywords
- Antimalarial drug
- Coptis japonica
- Drug-resistant malaria
- Kalopanax pictus
- Plasmodium falciparum
- Traditional Korean medicine
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science