Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

Masayuki Takahara, Akiko Kusano, Makio Shibano, Genjiro Kusano, Kenzo Koizumi, Ryuji Suzuki, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16, 23 : 23, 26 : 24, 25-triepoxy group in the side-chain moieties. Among the active triterpenoids, 9 also showed significant inhibition of nucleoside transport in mouse splenocytes. A relationship between the antimalarial activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.

Original languageEnglish
Pages (from-to)823-828
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume21
Issue number8
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • 9,19-cyclolanostane glycoside
  • Antimalarial activity
  • Cimicifuga
  • Nucleoside transport inhibition
  • Ranunculaceae
  • Thymidine-H uptake

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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