Antimalarial activities in vitro of homoprotoberberine derivatives. Design of novel antimalarials and structure-activity relationship analysis

Junji Miyata, Hiromi Nakashima, Hideo Nemoto, Hye Sook Kim, Yusuke Wataya, Masataka Ihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Antimalarial activities in vitro of homoprotoberberine derivatives against Plasmodium falciparum were examined. It has shown that 9-hydroxy- 2,3,10-trimethoxyhomoprotoberberine (10) was the most potent compound and the hydroxyl group at the C-9 position would play a significant role in exhibiting antimalarial activity and selective toxicity.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalHeterocycles
Volume49
Issue number1
DOIs
Publication statusPublished - Dec 31 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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