Antihepatotoxic actions of tannins

Hikino Hiroshi, Kiso Yoshinobu, Hatano Tsutomu, Yoshida Takashi, Okuda Takuo

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The antihepatotoxic effects of tannin analogues were examined utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most tannins showed significant antihepatotoxic effects in these two assay systems. Hydrolyzable tannins generally exhibited an intense enzyme inhibitory action on glutamic-pyruvic transaminase while condensed tannins exerted a much less inhibitory action, although variations were observed depending on structure. Structure-activity relationships are discussed.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalJournal of Ethnopharmacology
Volume14
Issue number1
DOIs
Publication statusPublished - Sep 1985

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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