Abstract
Chlorophyllin, a man-made water-soluble form of chlorophyll, is a focus of intensive studies from many laboratories for its antimutagenic and anticarcinogenic properties. Natural chlorophylls, in contrast, have been little studied in this regard. Since yellow-green vegetables are implicated to be protective against human cancers by epidemiological studies, it is important to explore the antigenotoxic properties of natural chlorophylls. Previously, we reported that a chlorophyll sample prepared from Chlorella vulgaris inhibited the mutagenicity of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b] a direct-acting mutagen, in Salmonella, and that the chlorophyll also showed inhibition of wing spot formation in Drosophila induced by 3-amino-1-methyl-5H-pyridor[4,3-b]indole (Trp-P-2). We have now prepared several samples of chlorophyll from spinach and chlorella, and studied their effect on the genotoxicity of 4-nitroquinoline 1-oxide (4NQO) in Drosophila The results showed that the genotoxicity of orally given 4NQO was suppressed by simultaneous administration of the chlorophylls. The mechanisms of this inhibition are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 97-100 |
| Number of pages | 4 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 376 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - May 12 1997 |
Fingerprint
Keywords
- 4-Nitroquinoline 1-oxide
- Antigenotoxicity
- Chlorophyll
- Drosophila wing spots
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
Cite this
Antigenotoxicity activity of natural chlorophylls. / Negishi, Tomoe; Rai, Haruki; Hayatsu, Hikoya.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 376, No. 1-2, 12.05.1997, p. 97-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antigenotoxicity activity of natural chlorophylls
AU - Negishi, Tomoe
AU - Rai, Haruki
AU - Hayatsu, Hikoya
PY - 1997/5/12
Y1 - 1997/5/12
N2 - Chlorophyllin, a man-made water-soluble form of chlorophyll, is a focus of intensive studies from many laboratories for its antimutagenic and anticarcinogenic properties. Natural chlorophylls, in contrast, have been little studied in this regard. Since yellow-green vegetables are implicated to be protective against human cancers by epidemiological studies, it is important to explore the antigenotoxic properties of natural chlorophylls. Previously, we reported that a chlorophyll sample prepared from Chlorella vulgaris inhibited the mutagenicity of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b] a direct-acting mutagen, in Salmonella, and that the chlorophyll also showed inhibition of wing spot formation in Drosophila induced by 3-amino-1-methyl-5H-pyridor[4,3-b]indole (Trp-P-2). We have now prepared several samples of chlorophyll from spinach and chlorella, and studied their effect on the genotoxicity of 4-nitroquinoline 1-oxide (4NQO) in Drosophila The results showed that the genotoxicity of orally given 4NQO was suppressed by simultaneous administration of the chlorophylls. The mechanisms of this inhibition are discussed.
AB - Chlorophyllin, a man-made water-soluble form of chlorophyll, is a focus of intensive studies from many laboratories for its antimutagenic and anticarcinogenic properties. Natural chlorophylls, in contrast, have been little studied in this regard. Since yellow-green vegetables are implicated to be protective against human cancers by epidemiological studies, it is important to explore the antigenotoxic properties of natural chlorophylls. Previously, we reported that a chlorophyll sample prepared from Chlorella vulgaris inhibited the mutagenicity of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b] a direct-acting mutagen, in Salmonella, and that the chlorophyll also showed inhibition of wing spot formation in Drosophila induced by 3-amino-1-methyl-5H-pyridor[4,3-b]indole (Trp-P-2). We have now prepared several samples of chlorophyll from spinach and chlorella, and studied their effect on the genotoxicity of 4-nitroquinoline 1-oxide (4NQO) in Drosophila The results showed that the genotoxicity of orally given 4NQO was suppressed by simultaneous administration of the chlorophylls. The mechanisms of this inhibition are discussed.
KW - 4-Nitroquinoline 1-oxide
KW - Antigenotoxicity
KW - Chlorophyll
KW - Drosophila wing spots
UR - http://www.scopus.com/inward/record.url?scp=0030976823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030976823&partnerID=8YFLogxK
U2 - 10.1016/S0027-5107(97)00030-4
DO - 10.1016/S0027-5107(97)00030-4
M3 - Article
C2 - 9202743
AN - SCOPUS:0030976823
VL - 376
SP - 97
EP - 100
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 1-2
ER -