Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis

Mayuko Osada-Oka, Yoshitaka Tateishi, Yukio Hirayama, Yuriko Ozeki, Mamiko Niki, Seigo Kitada, Ryoji Maekura, Kunio Tsujimura, Yukio Koide, Naoya Oohara, Taro Yamamoto, Kazuo Kobayashi, Sohkichi Matsumoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Development of accurate methods for predicting progression of tuberculosis (TB) from the latent state is recognized as vitally important in controlling TB, because a majority of cases develop from latent infections. Past TB that has never been treated has a higher risk of progressing than does latent Mycobacterium tuberculosis infection in patients who have previously received treatment. Antibody responses against 23 kinds of M. tuberculosis proteins in individuals with past TB who had not been medicated were evaluated. These individuals had significantly higher concentrations of antibodies against Antigen 85A and mycobacterial DNA-binding protein 1 (MDP1) than did those with active TB and uninfected controls. In addition, immunohistochemistry revealed colocalization of tubercle bacilli, antigen 85 and MDP1 inside tuberculous granuloma lesions in an asymptomatic subject, showing that M. tuberculosis in lesions expresses both antigen 85 and MDP1. Our study suggests the potential usefulness of measuring antibody responses to antigen 85A and MDP1 for assessing the risk of TB progression.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalMicrobiology and Immunology
Volume57
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

DNA-Binding Proteins
Tuberculosis
Immunoglobulin G
Antigens
Mycobacterium tuberculosis
Latent Tuberculosis
Antibody Formation
Mycobacterium Infections
Granuloma
Bacillus
Immunohistochemistry
Antibodies
Infection
Proteins

Keywords

  • Humoral response
  • Latent Mycobacterium tuberculosis infection
  • Rv2986c
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology

Cite this

Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis. / Osada-Oka, Mayuko; Tateishi, Yoshitaka; Hirayama, Yukio; Ozeki, Yuriko; Niki, Mamiko; Kitada, Seigo; Maekura, Ryoji; Tsujimura, Kunio; Koide, Yukio; Oohara, Naoya; Yamamoto, Taro; Kobayashi, Kazuo; Matsumoto, Sohkichi.

In: Microbiology and Immunology, Vol. 57, No. 1, 01.2013, p. 30-37.

Research output: Contribution to journalArticle

Osada-Oka, M, Tateishi, Y, Hirayama, Y, Ozeki, Y, Niki, M, Kitada, S, Maekura, R, Tsujimura, K, Koide, Y, Oohara, N, Yamamoto, T, Kobayashi, K & Matsumoto, S 2013, 'Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis', Microbiology and Immunology, vol. 57, no. 1, pp. 30-37. https://doi.org/10.1111/j.1348-0421.2012.12005.x
Osada-Oka, Mayuko ; Tateishi, Yoshitaka ; Hirayama, Yukio ; Ozeki, Yuriko ; Niki, Mamiko ; Kitada, Seigo ; Maekura, Ryoji ; Tsujimura, Kunio ; Koide, Yukio ; Oohara, Naoya ; Yamamoto, Taro ; Kobayashi, Kazuo ; Matsumoto, Sohkichi. / Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis. In: Microbiology and Immunology. 2013 ; Vol. 57, No. 1. pp. 30-37.
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