Antifungal drugs effect adherence of Candida albicans to acrylic surfaces by changing the zeta-potential of fungal cells

Yoichiro Miyake, Tatsuhiko Tsunoda, Shogo Minagi, Yasumasa Akagawa, Hiromichi Tsuru, Hidekazu Suginaka

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The effect of sub-inhibitory concentrations of antifungal drugs on the adherence of Candida albicans to acrylic surfaces was investigated. Among five antifungals tested, azalomycin F and aculeacin A significantly enhanced the adherence. The zeta-potential of fungal cells was affected by antifungal drugs, whereas no significant change in cell surface hydrophobicity was observed. The relationship obtained between the change in the adherence and that in zeta-potential suggests that the enhanced adherence was caused by decreased electric repulsive forces.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalFEMS Microbiology Letters
Volume69
Issue number3
DOIs
Publication statusPublished - Jun 1 1990
Externally publishedYes

Keywords

  • Acrylic resin
  • Adherence
  • Antifungal drug
  • Candida albicans
  • Zeta-potenital

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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