Antifungal activity of essential oils and their constituents against Candida Spp. and their effects on activity of amphotericin B

Akiko Nozaki; Eizo Takahashi; Keinosuke Okamoto; I. T.O. Hideyuki; Tsutomu Hatano

doi:10.1248/yakushi.130.895

Antifungal activity of essential oils and their constituents against Candida Spp. and their effects on activity of amphotericin B

Akiko Nozaki, Eizo Takahashi, Keinosuke Okamoto, I. T.O. Hideyuki, Tsutomu Hatano

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Candidiasis is a common opportunistic fungal infection that responds well to amphotericin B (AMPH) treatment. However, AMPH often causes adverse effects such as kidney injury and hypokalemia. Because some essential oils have been reported to have antifungal effects, we investigated the antifungal activity of various essential oils and their major constituents against Candida spp. Most essential oils examined in this study showed antifungal activity, and several enhanced the antifungal effect of AMPH. Clove oil in particular, and its major constituent eugenol, had potent effects. These findings suggest that combining certain essential oils or their constituents with AMPH may be useful for suppressing the adverse effects of AMPH treatment.

Original language	English
Pages (from-to)	895-902
Number of pages	8
Journal	Yakugaku Zasshi
Volume	130
Issue number	6
DOIs	https://doi.org/10.1248/yakushi.130.895
Publication status	Published - Jun 2010

Keywords

Amphotericin B
Antifungal effect
Candida
Clove oil
Essential oil
Eugenol

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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abstract = "Candidiasis is a common opportunistic fungal infection that responds well to amphotericin B (AMPH) treatment. However, AMPH often causes adverse effects such as kidney injury and hypokalemia. Because some essential oils have been reported to have antifungal effects, we investigated the antifungal activity of various essential oils and their major constituents against Candida spp. Most essential oils examined in this study showed antifungal activity, and several enhanced the antifungal effect of AMPH. Clove oil in particular, and its major constituent eugenol, had potent effects. These findings suggest that combining certain essential oils or their constituents with AMPH may be useful for suppressing the adverse effects of AMPH treatment.",

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AU - Takahashi, Eizo

AU - Okamoto, Keinosuke

AU - Hideyuki, I. T.O.

AU - Hatano, Tsutomu

PY - 2010/6

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AB - Candidiasis is a common opportunistic fungal infection that responds well to amphotericin B (AMPH) treatment. However, AMPH often causes adverse effects such as kidney injury and hypokalemia. Because some essential oils have been reported to have antifungal effects, we investigated the antifungal activity of various essential oils and their major constituents against Candida spp. Most essential oils examined in this study showed antifungal activity, and several enhanced the antifungal effect of AMPH. Clove oil in particular, and its major constituent eugenol, had potent effects. These findings suggest that combining certain essential oils or their constituents with AMPH may be useful for suppressing the adverse effects of AMPH treatment.

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Antifungal activity of essential oils and their constituents against Candida Spp. and their effects on activity of amphotericin B

Abstract

Keywords

ASJC Scopus subject areas

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