Antidepressant-like effect of 1α-hydroxyvitamin D3 on mice in the forced swimming test

Akihiko Kawaura, Yoshihisa Kitamura, Noritoshi Tanida, Junichi Akiyama, Masatoshi Mizutani, Kazuhiro Harada, Motoyoshi Morishita, Shigeki Inoue, Yoshio Kano, Toshio Okano, Eiji Takeda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We examined the effect of 1α-hydroxyvitamin D3 [1α(OH)D3] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D3 reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D3 had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D3 may have antidepressant-like activity.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalJournal of Nutritional Science and Vitaminology
Issue number1
Publication statusPublished - 2017


  • 1α-hydroxyvitamin D
  • Brain-derived neurotrophic factor
  • Forced swimming test
  • Glial cell line–derived neurotrophic factor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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