Anticonvulsant effect of 8α,9α- and 8β,9β-epoxyhexahydrocannabinols on pentylenetetrazol-induced seizures in the mouse

S. Narimatsu, I. Yamamoto, H. Yoshimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Anticonvulsant effect of 8α,9α- and 8β,9β-epoxyhexahydrocannabinols (EHHCs) on pentylenetetrazol (PTZ)-induced seizures was examined in mice and compared with that of Δ8-tetrahydrocannabinol (THC). After injection of PTZ, latency of clonic and tonic convulsions was longer in mice pretreated with these cannabinoids than that in the vehicle-pretreated control group. 8β,9β-EHHC was most effective in increasing latency, followed by Δ8-THC and 8α,9α-EHHC. Furthermore, most of the mice pretreated with cannabinoids did not show lethal tonic extension. In combination with phenobarbital, percent protection of tonic convulsion tended to be higher in 8β,9β-EHHC-pretreated mice than that in the group pretreated with other cannabinoids. From these results, the potency of anticonvulsant activity of the cannabinoids tested against PTZ-induced seizures was ranked in the following order; 8β,9β-EHHC > Δ8-THC > 8α,9α-EHHC.

Original languageEnglish
Pages (from-to)323-331
Number of pages9
JournalResearch Communications in Substances of Abuse
Volume3
Issue number3
Publication statusPublished - Jan 1 1982

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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