Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I

MAYUMI OGASAWARA; KOJI AOKI; EIJI MATSUURA; MITOSHI KUNIMATSU; IWAO OHKUBO; MONICA GALLI; MAKOTO SASAKI; YOSHIAKI YAGAMI

doi:10.1111/j.1600-0897.1995.tb00952.x

Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I

MAYUMI OGASAWARA, KOJI AOKI, EIJI MATSUURA, MITOSHI KUNIMATSU, IWAO OHKUBO, MONICA GALLI, MAKOTO SASAKI, YOSHIAKI YAGAMI

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

PROBLEM: Anticardiolipin antibodies (aCL) are commonly associated with recurrent pregnancy loss, though the mechanism is uncertain. Some investigators have indicated that aCL may be directed at a complex made up of cardiolipin and a blood anticoagulant, β2‐glycoprotein I (β2GPI). We therefore investigated the effects of β2GPI‐dependent aCL IgG enriched fractions, isolated from sera of patients with pregnancy losses, on blood coagulation. METHOD: β2GPI‐dependent aCL were prepared from sera of three women with second trimester pregnancy losses, by cardiolipin affinity column chromography, following by anti‐β2GPI affinity column chromatography. The effects of β2GPI and β2GPI‐dependent aCL on the activation of factor X in vitro were examined. RESULTS: β2GPI inhibited the activation of factor X and β2GPI‐dependent aCL blocked this inhibitory effect in a dose dependent manner. CONCLUSION: These results imply the possibility of β2GPI‐dependent aCL induce hypercoagulation or thrombus by blocking the inhibitory effect of β2GPI on activation of factor X, which may result in pregnancy loss. 1995 Munksgaard

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	American Journal of Reproductive Immunology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0897.1995.tb00952.x
Publication status	Published - Nov 1995
Externally published	Yes

Keywords

factor X
pregnancy loss
β2‐glycoprotein I
β2‐glycoprotein I dependent anticardiolipin antibodies

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynaecology

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10.1111/j.1600-0897.1995.tb00952.x

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OGASAWARA, MAYUMI., AOKI, KOJI., MATSUURA, EIJI., KUNIMATSU, MITOSHI., OHKUBO, IWAO., GALLI, MONICA., SASAKI, MAKOTO., & YAGAMI, YOSHIAKI. (1995). Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I. American Journal of Reproductive Immunology, 34(5), 269-273. https://doi.org/10.1111/j.1600-0897.1995.tb00952.x

OGASAWARA, MAYUMI, AOKI, KOJI, MATSUURA, EIJI, KUNIMATSU, MITOSHI, OHKUBO, IWAO, GALLI, MONICA, SASAKI, MAKOTO & YAGAMI, YOSHIAKI 1995, 'Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I', American Journal of Reproductive Immunology, vol. 34, no. 5, pp. 269-273. https://doi.org/10.1111/j.1600-0897.1995.tb00952.x

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title = "Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I",

abstract = "PROBLEM: Anticardiolipin antibodies (aCL) are commonly associated with recurrent pregnancy loss, though the mechanism is uncertain. Some investigators have indicated that aCL may be directed at a complex made up of cardiolipin and a blood anticoagulant, β2‐glycoprotein I (β2GPI). We therefore investigated the effects of β2GPI‐dependent aCL IgG enriched fractions, isolated from sera of patients with pregnancy losses, on blood coagulation. METHOD: β2GPI‐dependent aCL were prepared from sera of three women with second trimester pregnancy losses, by cardiolipin affinity column chromography, following by anti‐β2GPI affinity column chromatography. The effects of β2GPI and β2GPI‐dependent aCL on the activation of factor X in vitro were examined. RESULTS: β2GPI inhibited the activation of factor X and β2GPI‐dependent aCL blocked this inhibitory effect in a dose dependent manner. CONCLUSION: These results imply the possibility of β2GPI‐dependent aCL induce hypercoagulation or thrombus by blocking the inhibitory effect of β2GPI on activation of factor X, which may result in pregnancy loss. 1995 Munksgaard",

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author = "MAYUMI OGASAWARA and KOJI AOKI and EIJI MATSUURA and MITOSHI KUNIMATSU and IWAO OHKUBO and MONICA GALLI and MAKOTO SASAKI and YOSHIAKI YAGAMI",

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AU - OGASAWARA, MAYUMI

AU - AOKI, KOJI

AU - MATSUURA, EIJI

AU - KUNIMATSU, MITOSHI

AU - OHKUBO, IWAO

AU - GALLI, MONICA

AU - SASAKI, MAKOTO

AU - YAGAMI, YOSHIAKI

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N2 - PROBLEM: Anticardiolipin antibodies (aCL) are commonly associated with recurrent pregnancy loss, though the mechanism is uncertain. Some investigators have indicated that aCL may be directed at a complex made up of cardiolipin and a blood anticoagulant, β2‐glycoprotein I (β2GPI). We therefore investigated the effects of β2GPI‐dependent aCL IgG enriched fractions, isolated from sera of patients with pregnancy losses, on blood coagulation. METHOD: β2GPI‐dependent aCL were prepared from sera of three women with second trimester pregnancy losses, by cardiolipin affinity column chromography, following by anti‐β2GPI affinity column chromatography. The effects of β2GPI and β2GPI‐dependent aCL on the activation of factor X in vitro were examined. RESULTS: β2GPI inhibited the activation of factor X and β2GPI‐dependent aCL blocked this inhibitory effect in a dose dependent manner. CONCLUSION: These results imply the possibility of β2GPI‐dependent aCL induce hypercoagulation or thrombus by blocking the inhibitory effect of β2GPI on activation of factor X, which may result in pregnancy loss. 1995 Munksgaard

AB - PROBLEM: Anticardiolipin antibodies (aCL) are commonly associated with recurrent pregnancy loss, though the mechanism is uncertain. Some investigators have indicated that aCL may be directed at a complex made up of cardiolipin and a blood anticoagulant, β2‐glycoprotein I (β2GPI). We therefore investigated the effects of β2GPI‐dependent aCL IgG enriched fractions, isolated from sera of patients with pregnancy losses, on blood coagulation. METHOD: β2GPI‐dependent aCL were prepared from sera of three women with second trimester pregnancy losses, by cardiolipin affinity column chromography, following by anti‐β2GPI affinity column chromatography. The effects of β2GPI and β2GPI‐dependent aCL on the activation of factor X in vitro were examined. RESULTS: β2GPI inhibited the activation of factor X and β2GPI‐dependent aCL blocked this inhibitory effect in a dose dependent manner. CONCLUSION: These results imply the possibility of β2GPI‐dependent aCL induce hypercoagulation or thrombus by blocking the inhibitory effect of β2GPI on activation of factor X, which may result in pregnancy loss. 1995 Munksgaard

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Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I

Abstract

Keywords

ASJC Scopus subject areas

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