Antibody to Mac-1 or Monocyte Chemoattractant Protein-1 Inhibits Monocyte Recruitment and Promotes Tumor Growth

Lei Zhang, Teizo Yoshimura, Dana T. Graves

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Human tumors are frequently infiltrated by numerous monocytes/macrophages, which can be found within the tumor mass (intratumoral) or surrounding the tumor (peritumoral). The functional role that these monocytes/macrophages play in tumor growth is controversial. To address this issue we inhibited intratumoral monocyte/macrophage recruitment with mAbs that either blocked integrin function or neutralized a tumor-produced chemotactic protein. Both treatments significantly increased tumor formation and accelerated tumor growth. Surprisingly, the same results were obtained when recruitment of peritumoral or intratumoral monocytes/macrophages was blocked. Our findings are contrary to one of the purported roles of monocytes/ macrophages, particularly in the peritumoral area, since we found no evidence for monocyte/macrophage-supported tumor growth. These results provide direct evidence that intratumoral as well as peritumoral monocytes/macrophages act to limit tumor size in the early stages following tumor inoculation and provide a mechanism that accounts for monocyte/macrophage recruitment to human tumors.

Original languageEnglish
Pages (from-to)4855-4861
Number of pages7
JournalJournal of Immunology
Volume158
Issue number10
Publication statusPublished - May 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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