Antibiotic-resistant status and pathogenic clonal complex of canine Streptococcus canis-associated deep pyoderma

Ichiro Imanishi, Keita Iyori, Akira Také, Ryota Asahina, Manami Tsunoi, Ryuji Hirano, Jumpei Uchiyama, Yoichi Toyoda, Yoshihiko Sakaguchi, Shunji Hayashi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Streptococcus canis causes deep pyoderma in canines, which raises concerns about the risk of isolates from lesions acquiring an antibiotic-resistant phenotype. It is necessary to identify effective antibiotics and the characteristics of the pathogenic cluster for S. canis-associated deep pyoderma. Results: The signalment, molecular typing, and antibiotic-resistant status of S. canis isolated from deep pyoderma lesions (27 strains) and oral cavities (26 strains) were analyzed. Older dogs tended to have S. canis-associated deep pyoderma (15 of 27 dogs over 10 years old). Veterinarians chose quinolones for 10/16 cases (63%), even though the rate of quinolone-resistant strains of S. canis is 38–59%. Although 70% of the strains showed resistance to three or more antibiotic classes (37/53), 94% (50/53) strains showed sensitivity for penicillins. We also identified β-lactamase activity among penicillin-resistant strains of S. canis. Clonal complex 13 (CC13) was detected only in lesions and formed independent clusters in the phylogenetic tree. One strain of CC13 was resistant to the anti-methicillin-resistant Staphylococcus aureus drugs, vancomycin and linezolid. Conclusion: Although antibiotic-resistant strains of S. canis are isolated at a high rate, they can currently be treated with β-lactamase-inhibiting penicillins. CC13 may be a pathogenic cluster with high levels of antibiotics resistance.

Original languageEnglish
Article number395
JournalBMC Veterinary Research
Volume18
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Antibiotic resistance
  • Beta-lactamase
  • Dogs
  • Multilocus sequence typing
  • Opportunistic infections
  • Oral cavity
  • Pyoderma
  • Streptococcus

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint

Dive into the research topics of 'Antibiotic-resistant status and pathogenic clonal complex of canine Streptococcus canis-associated deep pyoderma'. Together they form a unique fingerprint.

Cite this