Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide

Rumiko Shimazawa, Hiroyuki Miyachi, Hisae Takayama, Kensei Kuroda, Fuminori Kato, Masanari Kato, Yuichi Hashimoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number2
Publication statusPublished - 1999
Externally publishedYes

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Keywords

  • Antiangiogenesis
  • Phthalimide
  • Thalidomide
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Shimazawa, R., Miyachi, H., Takayama, H., Kuroda, K., Kato, F., Kato, M., & Hashimoto, Y. (1999). Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide. Biological and Pharmaceutical Bulletin, 22(2), 224-226.