Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide

Rumiko Shimazawa; Hiroyuki Miyachi; Hisae Takayama; Kensei Kuroda; Fuminori Kato; Masanari Kato; Yuichi Hashimoto

doi:10.1248/bpb.22.224

Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide

Rumiko Shimazawa, Hiroyuki Miyachi, Hisae Takayama, Kensei Kuroda, Fuminori Kato, Masanari Kato, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.

Original language	English
Pages (from-to)	224-226
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	22
Issue number	2
DOIs	https://doi.org/10.1248/bpb.22.224
Publication status	Published - Feb 1999

Keywords

Antiangiogenesis
Phthalimide
Thalidomide
Tumor necrosis factor-α

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.22.224

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abstract = "Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.",

keywords = "Antiangiogenesis, Phthalimide, Thalidomide, Tumor necrosis factor-α",

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AU - Shimazawa, Rumiko

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AU - Kato, Fuminori

AU - Kato, Masanari

AU - Hashimoto, Yuichi

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KW - Thalidomide

KW - Tumor necrosis factor-α

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Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide

Abstract

Keywords

ASJC Scopus subject areas

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