Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide

Rumiko Shimazawa, Hiroyuki Miyachi, Hisae Takayama, Kensei Kuroda, Fuminori Kato, Masanari Kato, Yuichi Hashimoto

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 1999

Keywords

  • Antiangiogenesis
  • Phthalimide
  • Thalidomide
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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