Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L.

Toshio Inoue, Yukio Sugimoto, Hideki Masuda, Chiaki Kamei

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Six flavonoid glycosides, eriocitrin (1), narirutin (2), hesperidin (3), luteolin-7-O-rutinoside (4), isorhoifolin (5), diosmin (6), rosmarinic acid (7) and 5,7-dihydroxycromone-7-O-rutinoside (8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses of 100 and 300 mg/kg. These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 1 2002

Keywords

  • Antiallergic effect
  • Flavonoid glycoside
  • Histamine
  • Mentha piperita L.
  • Rat peritoneal mast cell

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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