Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice

Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yousuke Matsumoto, Motoi Okamoto, Yuko Fujiwara, Takeshi Ishihara

Research output: Contribution to journalArticle

Abstract

Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.

Original languageEnglish
Article numbere01945
JournalHeliyon
Volume5
Issue number6
DOIs
Publication statusPublished - Jun 1 2019

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Medicinal Plants
Plant Preparations
Water
Herbal Medicine
Body Temperature
Inbred C57BL Mouse
Oral Administration
Anxiety
Body Weight
Depression

Keywords

  • Neuroscience
  • Physiology

ASJC Scopus subject areas

  • General

Cite this

Ueno, H., Shimada, A., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., ... Ishihara, T. (2019). Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice. Heliyon, 5(6), [e01945]. https://doi.org/10.1016/j.heliyon.2019.e01945

Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice. / Ueno, Hiroshi; Shimada, Atsumi; Suemitsu, Shunsuke; Murakami, Shinji; Kitamura, Naoya; Wani, Kenta; Matsumoto, Yousuke; Okamoto, Motoi; Fujiwara, Yuko; Ishihara, Takeshi.

In: Heliyon, Vol. 5, No. 6, e01945, 01.06.2019.

Research output: Contribution to journalArticle

Ueno, H, Shimada, A, Suemitsu, S, Murakami, S, Kitamura, N, Wani, K, Matsumoto, Y, Okamoto, M, Fujiwara, Y & Ishihara, T 2019, 'Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice', Heliyon, vol. 5, no. 6, e01945. https://doi.org/10.1016/j.heliyon.2019.e01945
Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K et al. Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice. Heliyon. 2019 Jun 1;5(6). e01945. https://doi.org/10.1016/j.heliyon.2019.e01945
Ueno, Hiroshi ; Shimada, Atsumi ; Suemitsu, Shunsuke ; Murakami, Shinji ; Kitamura, Naoya ; Wani, Kenta ; Matsumoto, Yousuke ; Okamoto, Motoi ; Fujiwara, Yuko ; Ishihara, Takeshi. / Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice. In: Heliyon. 2019 ; Vol. 5, No. 6.
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