Abstract
Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
| Original language | English |
|---|---|
| Article number | e01945 |
| Journal | Heliyon |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2019 |
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Keywords
- Neuroscience
- Physiology
ASJC Scopus subject areas
- General
Cite this
Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice. / Ueno, Hiroshi; Shimada, Atsumi; Suemitsu, Shunsuke; Murakami, Shinji; Kitamura, Naoya; Wani, Kenta; Matsumoto, Yousuke; Okamoto, Motoi; Fujiwara, Yuko; Ishihara, Takeshi.
In: Heliyon, Vol. 5, No. 6, e01945, 01.06.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
AU - Ueno, Hiroshi
AU - Shimada, Atsumi
AU - Suemitsu, Shunsuke
AU - Murakami, Shinji
AU - Kitamura, Naoya
AU - Wani, Kenta
AU - Matsumoto, Yousuke
AU - Okamoto, Motoi
AU - Fujiwara, Yuko
AU - Ishihara, Takeshi
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
AB - Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
KW - Neuroscience
KW - Physiology
UR - http://www.scopus.com/inward/record.url?scp=85067204169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067204169&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2019.e01945
DO - 10.1016/j.heliyon.2019.e01945
M3 - Article
VL - 5
JO - Heliyon
JF - Heliyon
SN - 2405-8440
IS - 6
M1 - e01945
ER -