Anti-oxidative nutrient rich diet protects against acute ischemic brain damage in rats

Taijun Yunoki, Kentaro Deguchi, Yoshio Omote, Ning Liu, Wentao Liu, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We evaluated the neuroprotective effects of an anti-oxidative nutrient rich enteral diet (AO diet) that contained rich polyphenols (catechins and proanthocyanidins) and many other anti-oxidative ingredients. Wistar rats were treated with either vehicle, normal AO diet (containing 100 kcal/100 mL, catechin 38.75 mg/100 mL and proanthocyanidin 19 mg/ 100 mL, 1 mL/day), or high AO diet (containing 10 times the polyphenols of the normal AO diet) for 14 days, and were subjected to 90 min of transient middle cerebral artery occlusion. The AO diet improved motor function, reduced cerebral infarction volume, and decreased both peroxidative markers such as 4-hydroxynonenal, advanced glycation end products, 8-hydroxy-2-deoxyguanosine and inflammatory markers such as monocyte chemotactic protein-1, ionized calcium-binding adapter molecule-1, and tumor necrosis factor-α. Our study has shown that an AO diet has neuroprotective effects through both anti-oxidative and anti-inflammatory mechanisms, indicating that nutritional control with polyphenols could be useful for patients with acute ischemic stroke.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalBrain Research
Volume1587
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Diet
Food
Brain
Polyphenols
Catechin
Neuroprotective Agents
Proanthocyanidins
Advanced Glycosylation End Products
Chemokine CCL2
Middle Cerebral Artery Infarction
Cerebral Infarction
Small Intestine
Wistar Rats
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Stroke
Calcium

Keywords

  • Anti-inflammatory
  • Anti-oxidative
  • Cerebral infarction
  • Middle cerebral artery occlusion
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Anti-oxidative nutrient rich diet protects against acute ischemic brain damage in rats. / Yunoki, Taijun; Deguchi, Kentaro; Omote, Yoshio; Liu, Ning; Liu, Wentao; Hishikawa, Nozomi; Yamashita, Toru; Abe, Koji.

In: Brain Research, Vol. 1587, No. 1, 2014, p. 33-39.

Research output: Contribution to journalArticle

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