Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat

Takehiro Nakamura, Shinji Tanaka, Kazuyuki Hirooka, Tetsuhiko Toyoshima, Nobuyuki Kawai, Takashi Tamiya, Fumio Shiraga, Masaaki Tokuda, Richard F. Keep, Toshifumi Itano, Osamu Miyamoto

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Abstract

The present study investigates the anti-oxidative effects of d-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1. h under pentobarbital anesthesia. d-allose was intravenously infused during occlusion and a further 1. h after reperfusion (400. mg/kg). The effects of d-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24. h after MCAO to examine the anti-oxidative effects of d-allose. Brain damage and behavioral deficits were significantly decreased by d-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by d-allose. Thus, the present study suggests that d-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalNeuroscience Letters
Volume487
Issue number1
DOIs
Publication statusPublished - Jan 3 2011

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Keywords

  • Behavior
  • Ischemia
  • Oxidation
  • Rare sugar
  • Rat
  • Reperfusion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nakamura, T., Tanaka, S., Hirooka, K., Toyoshima, T., Kawai, N., Tamiya, T., Shiraga, F., Tokuda, M., Keep, R. F., Itano, T., & Miyamoto, O. (2011). Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat. Neuroscience Letters, 487(1), 103-106. https://doi.org/10.1016/j.neulet.2010.10.004