Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat

Takehiro Nakamura; Shinji Tanaka; Kazuyuki Hirooka; Tetsuhiko Toyoshima; Nobuyuki Kawai; Takashi Tamiya; Fumio Shiraga; Masaaki Tokuda; Richard F. Keep; Toshifumi Itano; Osamu Miyamoto

doi:10.1016/j.neulet.2010.10.004

Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat

Takehiro Nakamura, Shinji Tanaka, Kazuyuki Hirooka, Tetsuhiko Toyoshima, Nobuyuki Kawai, Takashi Tamiya, Fumio Shiraga, Masaaki Tokuda, Richard F. Keep, Toshifumi Itano, Osamu Miyamoto

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42 Citations (Scopus)

Abstract

The present study investigates the anti-oxidative effects of d-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1. h under pentobarbital anesthesia. d-allose was intravenously infused during occlusion and a further 1. h after reperfusion (400. mg/kg). The effects of d-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24. h after MCAO to examine the anti-oxidative effects of d-allose. Brain damage and behavioral deficits were significantly decreased by d-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by d-allose. Thus, the present study suggests that d-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Neuroscience Letters
Volume	487
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2010.10.004
Publication status	Published - Jan 3 2011
Externally published	Yes

Keywords

Behavior
Ischemia
Oxidation
Rare sugar
Rat
Reperfusion

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2010.10.004

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title = "Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat",

abstract = "The present study investigates the anti-oxidative effects of d-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1. h under pentobarbital anesthesia. d-allose was intravenously infused during occlusion and a further 1. h after reperfusion (400. mg/kg). The effects of d-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24. h after MCAO to examine the anti-oxidative effects of d-allose. Brain damage and behavioral deficits were significantly decreased by d-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by d-allose. Thus, the present study suggests that d-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia.",

keywords = "Behavior, Ischemia, Oxidation, Rare sugar, Rat, Reperfusion",

author = "Takehiro Nakamura and Shinji Tanaka and Kazuyuki Hirooka and Tetsuhiko Toyoshima and Nobuyuki Kawai and Takashi Tamiya and Fumio Shiraga and Masaaki Tokuda and Keep, {Richard F.} and Toshifumi Itano and Osamu Miyamoto",

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AU - Nakamura, Takehiro

AU - Tanaka, Shinji

AU - Hirooka, Kazuyuki

AU - Toyoshima, Tetsuhiko

AU - Kawai, Nobuyuki

AU - Tamiya, Takashi

AU - Shiraga, Fumio

AU - Tokuda, Masaaki

AU - Keep, Richard F.

AU - Itano, Toshifumi

AU - Miyamoto, Osamu

PY - 2011/1/3

Y1 - 2011/1/3

N2 - The present study investigates the anti-oxidative effects of d-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1. h under pentobarbital anesthesia. d-allose was intravenously infused during occlusion and a further 1. h after reperfusion (400. mg/kg). The effects of d-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24. h after MCAO to examine the anti-oxidative effects of d-allose. Brain damage and behavioral deficits were significantly decreased by d-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by d-allose. Thus, the present study suggests that d-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia.

AB - The present study investigates the anti-oxidative effects of d-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1. h under pentobarbital anesthesia. d-allose was intravenously infused during occlusion and a further 1. h after reperfusion (400. mg/kg). The effects of d-allose on focal cerebral ischemia were examined by measuring brain damage (infarction and atrophy volume) and behavioral deficits 7 days after MCAO. In another set of rats, apurnic/apyrimidic abasic sites (AP-sites) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were investigated 24. h after MCAO to examine the anti-oxidative effects of d-allose. Brain damage and behavioral deficits were significantly decreased by d-allose administration compared to vehicle. The number of AP-sites and 8-OHdG levels were also reduced by d-allose. Thus, the present study suggests that d-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia.

KW - Behavior

KW - Ischemia

KW - Oxidation

KW - Rare sugar

KW - Rat

KW - Reperfusion

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Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat

Abstract

Keywords

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