Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

Yukitaka Kimura, Hiroyuki Kanatani, Motohiro Shima, Shuji Adachi, Ryuichi Matsuno

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

Original languageEnglish
Pages (from-to)1723-1727
Number of pages5
JournalBiotechnology Letters
Volume25
Issue number20
DOIs
Publication statusPublished - Oct 2003
Externally publishedYes

Fingerprint

Oxidants
Epithelial Cells
Ascorbic acid
Chain length
Ascorbic Acid
Monolayers
Cell Line

Keywords

  • Acyl ascorbate
  • Anti-oxidant activity
  • Human intestinal epithelial cell
  • Oxidization state

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this

Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells. / Kimura, Yukitaka; Kanatani, Hiroyuki; Shima, Motohiro; Adachi, Shuji; Matsuno, Ryuichi.

In: Biotechnology Letters, Vol. 25, No. 20, 10.2003, p. 1723-1727.

Research output: Contribution to journalArticle

Kimura, Yukitaka ; Kanatani, Hiroyuki ; Shima, Motohiro ; Adachi, Shuji ; Matsuno, Ryuichi. / Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells. In: Biotechnology Letters. 2003 ; Vol. 25, No. 20. pp. 1723-1727.
@article{409bc795a9dd4149a8719d1d08b267cc,
title = "Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells",
abstract = "The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.",
keywords = "Acyl ascorbate, Anti-oxidant activity, Human intestinal epithelial cell, Oxidization state",
author = "Yukitaka Kimura and Hiroyuki Kanatani and Motohiro Shima and Shuji Adachi and Ryuichi Matsuno",
year = "2003",
month = "10",
doi = "10.1023/A:1026098519848",
language = "English",
volume = "25",
pages = "1723--1727",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "Springer Netherlands",
number = "20",

}

TY - JOUR

T1 - Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

AU - Kimura, Yukitaka

AU - Kanatani, Hiroyuki

AU - Shima, Motohiro

AU - Adachi, Shuji

AU - Matsuno, Ryuichi

PY - 2003/10

Y1 - 2003/10

N2 - The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

AB - The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

KW - Acyl ascorbate

KW - Anti-oxidant activity

KW - Human intestinal epithelial cell

KW - Oxidization state

UR - http://www.scopus.com/inward/record.url?scp=0142152592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142152592&partnerID=8YFLogxK

U2 - 10.1023/A:1026098519848

DO - 10.1023/A:1026098519848

M3 - Article

C2 - 14626415

AN - SCOPUS:0142152592

VL - 25

SP - 1723

EP - 1727

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 20

ER -