Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

Yukitaka Kimura; Hiroyuki Kanatani; Motohiro Shima; Shuji Adachi; Ryuichi Matsuno

doi:10.1023/A:1026098519848

Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

Yukitaka Kimura, Hiroyuki Kanatani, Motohiro Shima, Shuji Adachi, Ryuichi Matsuno

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 ^-12 to 3 × 10^-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

Original language	English
Pages (from-to)	1723-1727
Number of pages	5
Journal	Biotechnology Letters
Volume	25
Issue number	20
DOIs	https://doi.org/10.1023/A:1026098519848
Publication status	Published - Oct 2003
Externally published	Yes

Keywords

Acyl ascorbate
Anti-oxidant activity
Human intestinal epithelial cell
Oxidization state

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1023/A:1026098519848

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title = "Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells",

abstract = "The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.",

keywords = "Acyl ascorbate, Anti-oxidant activity, Human intestinal epithelial cell, Oxidization state",

author = "Yukitaka Kimura and Hiroyuki Kanatani and Motohiro Shima and Shuji Adachi and Ryuichi Matsuno",

note = "Funding Information: This study was supported by a Grant-in-Aid for Scientific Research (Grant No. 12460057) from the Japan Society for Promotion of Science.",

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T1 - Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

AU - Kimura, Yukitaka

AU - Kanatani, Hiroyuki

AU - Shima, Motohiro

AU - Adachi, Shuji

AU - Matsuno, Ryuichi

N1 - Funding Information: This study was supported by a Grant-in-Aid for Scientific Research (Grant No. 12460057) from the Japan Society for Promotion of Science.

PY - 2003/10

Y1 - 2003/10

N2 - The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

AB - The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

KW - Acyl ascorbate

KW - Anti-oxidant activity

KW - Human intestinal epithelial cell

KW - Oxidization state

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JO - Biotechnology Letters

JF - Biotechnology Letters

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Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

Abstract

Keywords

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