Anti-oxidant activity of acyl ascorbates in intestinal epithelial cells

Yukitaka Kimura, Hiroyuki Kanatani, Motohiro Shima, Shuji Adachi, Ryuichi Matsuno

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The anti-oxidant activity of acyl ascorbates, with acyl chain lengths of 10 to 18, was measured in an intestinal epithelial cell line. All the acyl ascorbates exhibited the activity for the oxidization induced by three different types of oxidants, at levels higher than ascorbic acid. Myristoyl ascorbate was the most effective and showed activity at 3 × 10 -12 to 3 × 10-6 M. Incubation with myristoyl ascorbate for more than 3 h was needed to sufficiently suppress the oxidization of the intestinal cell monolayers.

Original languageEnglish
Pages (from-to)1723-1727
Number of pages5
JournalBiotechnology Letters
Volume25
Issue number20
DOIs
Publication statusPublished - Oct 1 2003
Externally publishedYes

Keywords

  • Acyl ascorbate
  • Anti-oxidant activity
  • Human intestinal epithelial cell
  • Oxidization state

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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