Anti-N-methyl-D-aspartate receptor encephalitis in psychiatry

Shinji Sakamoto, Hiroki Kawai, Yuko Okahisa, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Yutaka Mizuki, Manabu Takaki, Norihito Yamada

Research output: Contribution to journalReview articlepeer-review

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti- NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalActa medica Okayama
Volume73
Issue number3
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Encephalitis
  • Mood disorder
  • NMDAR
  • Psychiatric symptom
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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