Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis

Nao Otsuka, Mei Hua Liu, Sumiko Shiota, Wakano Ogawa, Teruo Kuroda, Tsutomu Hatano, Tomofusa Tsuchiya

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3-O-α-L-(2″,4″-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol 3-O-α-L-(2″-Z-p-coumaroyl-4″-E-p- coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae, Pseudomonas aeruginosa and Serratia marcescens.

Original languageEnglish
Pages (from-to)1794-1797
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Laurus
Methicillin-Resistant Staphylococcus aureus
Lauraceae
Serratia marcescens
Streptococcus pneumoniae
Flavonoids
Pseudomonas aeruginosa

Keywords

  • Anti-methicillin-resistant Staphylococcus aureus compound
  • Anti-vancomycin-resistant enterococci
  • Laurus nobilis
  • Methicillin-resistant Staphylococcus aureus
  • Vancomycin-resistant enterococci

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis. / Otsuka, Nao; Liu, Mei Hua; Shiota, Sumiko; Ogawa, Wakano; Kuroda, Teruo; Hatano, Tsutomu; Tsuchiya, Tomofusa.

In: Biological and Pharmaceutical Bulletin, Vol. 31, No. 9, 09.2008, p. 1794-1797.

Research output: Contribution to journalArticle

Otsuka, Nao ; Liu, Mei Hua ; Shiota, Sumiko ; Ogawa, Wakano ; Kuroda, Teruo ; Hatano, Tsutomu ; Tsuchiya, Tomofusa. / Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis. In: Biological and Pharmaceutical Bulletin. 2008 ; Vol. 31, No. 9. pp. 1794-1797.
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