Anti-malarial activities of acylated bruceolide derivatives

Nobutoshi Murakarni; Takashi Umezome; Taifo Mahmud; Masanori Sugimoto; Motomasa Kobayashi; Yusuke Wataya; Hye Sook Kim

doi:10.1016/S0960-894X(98)00045-6

Anti-malarial activities of acylated bruceolide derivatives

Nobutoshi Murakarni, Takashi Umezome, Taifo Mahmud, Masanori Sugimoto, Motomasa Kobayashi, Yusuke Wataya, Hye Sook Kim

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.

Original language	English
Pages (from-to)	459-462
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(98)00045-6
Publication status	Published - Mar 3 1998

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ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Murakarni, N., Umezome, T., Mahmud, T., Sugimoto, M., Kobayashi, M., Wataya, Y., & Kim, H. S. (1998). Anti-malarial activities of acylated bruceolide derivatives. Bioorganic and Medicinal Chemistry Letters, 8(5), 459-462. https://doi.org/10.1016/S0960-894X(98)00045-6

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10.1016/S0960-894X(98)00045-6