TY - JOUR
T1 - Anti-malarial activities of acylated bruceolide derivatives
AU - Murakarni, Nobutoshi
AU - Umezome, Takashi
AU - Mahmud, Taifo
AU - Sugimoto, Masanori
AU - Kobayashi, Motomasa
AU - Wataya, Yusuke
AU - Kim, Hye Sook
N1 - Funding Information:
Acknowledgment : This study was financially supported by a Grant-in-Aid for Scientific Research (08281105) from the Ministry of Education, Science, Sports, and Culture of Japan. The authors are also grateful to the Kanae Foundation for Life and Socio-medical Science for financial support.
PY - 1998/3/3
Y1 - 1998/3/3
N2 - Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
AB - Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
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U2 - 10.1016/S0960-894X(98)00045-6
DO - 10.1016/S0960-894X(98)00045-6
M3 - Article
C2 - 9871598
AN - SCOPUS:0032478058
VL - 8
SP - 459
EP - 462
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 5
ER -