Anti-malarial activities of acylated bruceolide derivatives

Nobutoshi Murakarni, Takashi Umezome, Taifo Mahmud, Masanori Sugimoto, Motomasa Kobayashi, Yusuke Wataya, Hye Sook Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number5
DOIs
Publication statusPublished - Mar 3 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Murakarni, N., Umezome, T., Mahmud, T., Sugimoto, M., Kobayashi, M., Wataya, Y., & Kim, H. S. (1998). Anti-malarial activities of acylated bruceolide derivatives. Bioorganic and Medicinal Chemistry Letters, 8(5), 459-462. https://doi.org/10.1016/S0960-894X(98)00045-6