Anti-malarial activities of acylated bruceolide derivatives

Nobutoshi Murakarni; Takashi Umezome; Taifo Mahmud; Masanori Sugimoto; Motomasa Kobayashi; Yusuke Wataya; Hye Sook Kim

doi:10.1016/S0960-894X(98)00045-6

Anti-malarial activities of acylated bruceolide derivatives

Nobutoshi Murakarni, Takashi Umezome, Taifo Mahmud, Masanori Sugimoto, Motomasa Kobayashi, Yusuke Wataya, Hye Sook Kim

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.

Original language	English
Pages (from-to)	459-462
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(98)00045-6
Publication status	Published - Mar 3 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Anti-malarial activities of acylated bruceolide derivatives",

abstract = "Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.",

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AU - Murakarni, Nobutoshi

AU - Umezome, Takashi

AU - Mahmud, Taifo

AU - Sugimoto, Masanori

AU - Kobayashi, Motomasa

AU - Wataya, Yusuke

AU - Kim, Hye Sook

PY - 1998/3/3

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AB - Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.

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