Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells

Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Satoshi Nagase, Hiroshi Morita, Fukushima Kusano Kengo, Tohru Ohe, Kazuhiko Ishihara

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 μM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalJournal of Pharmacological Sciences
Volume101
Issue number3
DOIs
Publication statusPublished - 2006

Fingerprint

Spironolactone
Blood Cells
Anti-Inflammatory Agents
Angiotensin II
Chemokine CCL2
Tumor Necrosis Factor-alpha
Cardiovascular Diseases
Cytokines
Inflammation
alacepril
candesartan

Keywords

  • Angiotensin II
  • Peripheral blood mononuclear cell
  • Spironolactone

ASJC Scopus subject areas

  • Pharmacology

Cite this

Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells. / Miura, Ryuzea; Nakamura, Kazufumi; Miura, Daiji; Miura, Aya; Hisamatsu, Kenichi; Kajiya, Masahito; Nagase, Satoshi; Morita, Hiroshi; Kengo, Fukushima Kusano; Ohe, Tohru; Ishihara, Kazuhiko.

In: Journal of Pharmacological Sciences, Vol. 101, No. 3, 2006, p. 256-259.

Research output: Contribution to journalArticle

Miura, R, Nakamura, K, Miura, D, Miura, A, Hisamatsu, K, Kajiya, M, Nagase, S, Morita, H, Kengo, FK, Ohe, T & Ishihara, K 2006, 'Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells', Journal of Pharmacological Sciences, vol. 101, no. 3, pp. 256-259. https://doi.org/10.1254/jphs.SC0060049
Miura, Ryuzea ; Nakamura, Kazufumi ; Miura, Daiji ; Miura, Aya ; Hisamatsu, Kenichi ; Kajiya, Masahito ; Nagase, Satoshi ; Morita, Hiroshi ; Kengo, Fukushima Kusano ; Ohe, Tohru ; Ishihara, Kazuhiko. / Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells. In: Journal of Pharmacological Sciences. 2006 ; Vol. 101, No. 3. pp. 256-259.
@article{6e178879e93a4a4f8c04e3e464d79971,
title = "Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells",
abstract = "We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 μM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.",
keywords = "Angiotensin II, Peripheral blood mononuclear cell, Spironolactone",
author = "Ryuzea Miura and Kazufumi Nakamura and Daiji Miura and Aya Miura and Kenichi Hisamatsu and Masahito Kajiya and Satoshi Nagase and Hiroshi Morita and Kengo, {Fukushima Kusano} and Tohru Ohe and Kazuhiko Ishihara",
year = "2006",
doi = "10.1254/jphs.SC0060049",
language = "English",
volume = "101",
pages = "256--259",
journal = "Journal of Pharmacological Sciences",
issn = "1347-8648",
publisher = "The Japanese Pharmacological Society",
number = "3",

}

TY - JOUR

T1 - Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells

AU - Miura, Ryuzea

AU - Nakamura, Kazufumi

AU - Miura, Daiji

AU - Miura, Aya

AU - Hisamatsu, Kenichi

AU - Kajiya, Masahito

AU - Nagase, Satoshi

AU - Morita, Hiroshi

AU - Kengo, Fukushima Kusano

AU - Ohe, Tohru

AU - Ishihara, Kazuhiko

PY - 2006

Y1 - 2006

N2 - We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 μM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

AB - We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 μM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

KW - Angiotensin II

KW - Peripheral blood mononuclear cell

KW - Spironolactone

UR - http://www.scopus.com/inward/record.url?scp=33746343979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746343979&partnerID=8YFLogxK

U2 - 10.1254/jphs.SC0060049

DO - 10.1254/jphs.SC0060049

M3 - Article

VL - 101

SP - 256

EP - 259

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8648

IS - 3

ER -