Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells

Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Satoshi Nagase, Hiroshi Morita, Fukushima Kusano Kengo, Tohru Ohe, Kazuhiko Ishihara

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21 Citations (Scopus)

Abstract

We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 μM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalJournal of Pharmacological Sciences
Volume101
Issue number3
DOIs
Publication statusPublished - 2006

Keywords

  • Angiotensin II
  • Peripheral blood mononuclear cell
  • Spironolactone

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    Miura, R., Nakamura, K., Miura, D., Miura, A., Hisamatsu, K., Kajiya, M., Nagase, S., Morita, H., Kengo, F. K., Ohe, T., & Ishihara, K. (2006). Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells. Journal of Pharmacological Sciences, 101(3), 256-259. https://doi.org/10.1254/jphs.SC0060049