Anti-high mobility group box-1 antibody therapy for traumatic brain injury

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is one of the major causes of death and aftereŠects in young individuals worldwide; however, efficient therapies for TBI are lacking at present. High mobility group box-1 (HMGB-1), which is recognized as a representative of danger-associated molecular patterns (DAMPs), plays an important role in triggering inflammatory responses in many types of diseases.We presented the involvement of HMGB-1 in TBI and evaluated the ability of intravenously administered neutralizing anti-HMGB-1 monoclonal antibody (mAb) to attenuate brain injury. Anti-HMGB-1 mAb may provide a novel and eŠective therapy for TBI by protecting against blood brain barrier disruption and reducing the inflammatory responses induced by HMGB-1.

Original languageEnglish
Pages (from-to)701-705
Number of pages5
JournalYakugaku Zasshi
Volume134
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • High mobility group box-1
  • Secondary injury
  • Traumatic brain injury

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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