Abstract
Background: Helicobacter pylori eradication therapy was approved in Japan for the first-line, standard treatment of H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small-scale single-center studies have been reported, a prospective, large-scale, nationwide, multicenter study has not been reported from Japan. Materials and Methods: We conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole-based triple H. pylori eradication therapy for patients with localized gastric MALT lymphoma in practice-based clinical trial. A total of 108 H. pylori-positive patients with stage I/II1 gastric MALT lymphoma underwent H. pylori eradication therapy. The primary endpoints were complete remission (CR) rate and the rate of transfer to secondary treatment. The secondary endpoints were CR maintenance duration and overall survival (OS). Results: CR of lymphoma was achieved in 84 of 97 patients (86.6%), during the period 2.0-44.7 months (median, 5.3 months) after starting H. pylori eradication treatment. CR was maintained in 77 of 81 patients (95.1%) for 0.4-53.2 months (median, 33.1 months). Secondary treatments (radiotherapy, rituximab, or gastrectomy) for gastric MALT lymphoma were needed in 10 of the 97 patients (10.31%). During follow-up, OS rate was 96.9% (94/97) and the causes of 3 deaths were not related to lymphoma. Conclusions: Rabeprazole-based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice-based, multicenter study.
| Original language | English |
|---|---|
| Article number | e12474 |
| Journal | Helicobacter |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1 2018 |
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Keywords
- gastric MALT lymphoma
- Helicobacter pylori eradication
- prospective nationwide multicenter study
- rabeprazole-based triple therapy
ASJC Scopus subject areas
- Gastroenterology
- Infectious Diseases
Cite this
Anti-Helicobacter pylori therapy in localized gastric mucosa-associated lymphoid tissue lymphoma : A prospective, nationwide, multicenter study in Japan. / Sugizaki, Katsuya; Tari, Akira; Kitadai, Yasuhiko; Oda, Ichiro; Nakamura, Shotaro; Yoshino, Tadashi; Sugiyama, Toshiro.
In: Helicobacter, Vol. 23, No. 2, e12474, 01.04.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-Helicobacter pylori therapy in localized gastric mucosa-associated lymphoid tissue lymphoma
T2 - A prospective, nationwide, multicenter study in Japan
AU - Sugizaki, Katsuya
AU - Tari, Akira
AU - Kitadai, Yasuhiko
AU - Oda, Ichiro
AU - Nakamura, Shotaro
AU - Yoshino, Tadashi
AU - Sugiyama, Toshiro
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: Helicobacter pylori eradication therapy was approved in Japan for the first-line, standard treatment of H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small-scale single-center studies have been reported, a prospective, large-scale, nationwide, multicenter study has not been reported from Japan. Materials and Methods: We conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole-based triple H. pylori eradication therapy for patients with localized gastric MALT lymphoma in practice-based clinical trial. A total of 108 H. pylori-positive patients with stage I/II1 gastric MALT lymphoma underwent H. pylori eradication therapy. The primary endpoints were complete remission (CR) rate and the rate of transfer to secondary treatment. The secondary endpoints were CR maintenance duration and overall survival (OS). Results: CR of lymphoma was achieved in 84 of 97 patients (86.6%), during the period 2.0-44.7 months (median, 5.3 months) after starting H. pylori eradication treatment. CR was maintained in 77 of 81 patients (95.1%) for 0.4-53.2 months (median, 33.1 months). Secondary treatments (radiotherapy, rituximab, or gastrectomy) for gastric MALT lymphoma were needed in 10 of the 97 patients (10.31%). During follow-up, OS rate was 96.9% (94/97) and the causes of 3 deaths were not related to lymphoma. Conclusions: Rabeprazole-based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice-based, multicenter study.
AB - Background: Helicobacter pylori eradication therapy was approved in Japan for the first-line, standard treatment of H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small-scale single-center studies have been reported, a prospective, large-scale, nationwide, multicenter study has not been reported from Japan. Materials and Methods: We conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole-based triple H. pylori eradication therapy for patients with localized gastric MALT lymphoma in practice-based clinical trial. A total of 108 H. pylori-positive patients with stage I/II1 gastric MALT lymphoma underwent H. pylori eradication therapy. The primary endpoints were complete remission (CR) rate and the rate of transfer to secondary treatment. The secondary endpoints were CR maintenance duration and overall survival (OS). Results: CR of lymphoma was achieved in 84 of 97 patients (86.6%), during the period 2.0-44.7 months (median, 5.3 months) after starting H. pylori eradication treatment. CR was maintained in 77 of 81 patients (95.1%) for 0.4-53.2 months (median, 33.1 months). Secondary treatments (radiotherapy, rituximab, or gastrectomy) for gastric MALT lymphoma were needed in 10 of the 97 patients (10.31%). During follow-up, OS rate was 96.9% (94/97) and the causes of 3 deaths were not related to lymphoma. Conclusions: Rabeprazole-based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice-based, multicenter study.
KW - gastric MALT lymphoma
KW - Helicobacter pylori eradication
KW - prospective nationwide multicenter study
KW - rabeprazole-based triple therapy
UR - http://www.scopus.com/inward/record.url?scp=85043302145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043302145&partnerID=8YFLogxK
U2 - 10.1111/hel.12474
DO - 10.1111/hel.12474
M3 - Article
C2 - 29504247
AN - SCOPUS:85043302145
VL - 23
JO - Helicobacter
JF - Helicobacter
SN - 1083-4389
IS - 2
M1 - e12474
ER -