Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

Hiroko Sano; Tomomi Noguchi; Atsushi Miyajima; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1016/j.bmcl.2006.02.021

Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

Hiroko Sano, Tomomi Noguchi, Atsushi Miyajima, Yuichi Hashimoto, Hiroyuki Miyachi

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).

Original language	English
Pages (from-to)	3068-3072
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2006.02.021
Publication status	Published - Jun 1 2006

Keywords

Angiogenesis
COX-1
COX-1 inhibitor
HUVEC

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2006.02.021

Cite this

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title = "Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors",

abstract = "Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).",

keywords = "Angiogenesis, COX-1, COX-1 inhibitor, HUVEC",

author = "Hiroko Sano and Tomomi Noguchi and Atsushi Miyajima and Yuichi Hashimoto and Hiroyuki Miyachi",

note = "Funding Information: We thank Dr. Hideki Nohara (University of Tokyo) for helpful discussions and technical assistance. The work described here was partly supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science. ",

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doi = "10.1016/j.bmcl.2006.02.021",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

AU - Sano, Hiroko

AU - Noguchi, Tomomi

AU - Miyajima, Atsushi

AU - Hashimoto, Yuichi

AU - Miyachi, Hiroyuki

N1 - Funding Information: We thank Dr. Hideki Nohara (University of Tokyo) for helpful discussions and technical assistance. The work described here was partly supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science.

PY - 2006/6/1

Y1 - 2006/6/1

N2 - Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).

AB - Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).

KW - Angiogenesis

KW - COX-1

KW - COX-1 inhibitor

KW - HUVEC

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SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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