Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

Hiroko Sano, Tomomi Noguchi, Atsushi Miyajima, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).

Original languageEnglish
Pages (from-to)3068-3072
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number11
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

Fingerprint

Cyclooxygenase 1
Cyclooxygenase Inhibitors
Endothelial cells
Human Umbilical Vein Endothelial Cells
indole
indoline

Keywords

  • Angiogenesis
  • COX-1
  • COX-1 inhibitor
  • HUVEC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors. / Sano, Hiroko; Noguchi, Tomomi; Miyajima, Atsushi; Hashimoto, Yuichi; Miyachi, Hiroyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 11, 01.06.2006, p. 3068-3072.

Research output: Contribution to journalArticle

Sano, Hiroko ; Noguchi, Tomomi ; Miyajima, Atsushi ; Hashimoto, Yuichi ; Miyachi, Hiroyuki. / Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 11. pp. 3068-3072.
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