Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

Hiroko Sano, Tomomi Noguchi, Atsushi Miyajima, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).

Original languageEnglish
Pages (from-to)3068-3072
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
Publication statusPublished - Jun 1 2006


  • Angiogenesis
  • COX-1
  • COX-1 inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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