Anti-allergic inflammatory effects of hepatocyte growth factor.

Wataru Ito, Masahide Takeda, Masako Tanabe, Junko Kihara, Hikari Kato, Takahito Chiba, Kazutoshi Yamaguchi, Shigeharu Ueki, Arihiko Kanehiro, Hiroyuki Kayaba, Junichi Chihara

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-beta in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalInternational archives of allergy and immunology
Volume146 Suppl 1
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Ito, W., Takeda, M., Tanabe, M., Kihara, J., Kato, H., Chiba, T., Yamaguchi, K., Ueki, S., Kanehiro, A., Kayaba, H., & Chihara, J. (2008). Anti-allergic inflammatory effects of hepatocyte growth factor. International archives of allergy and immunology, 146 Suppl 1, 82-87. https://doi.org/10.1159/000126067