Abstract
Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-beta in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions.
| Original language | English |
|---|---|
| Pages (from-to) | 82-87 |
| Number of pages | 6 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 146 Suppl 1 |
| DOIs | |
| Publication status | Published - 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Anti-allergic inflammatory effects of hepatocyte growth factor. / Ito, Wataru; Takeda, Masahide; Tanabe, Masako; Kihara, Junko; Kato, Hikari; Chiba, Takahito; Yamaguchi, Kazutoshi; Ueki, Shigeharu; Kanehiro, Arihiko; Kayaba, Hiroyuki; Chihara, Junichi.
In: International Archives of Allergy and Immunology, Vol. 146 Suppl 1, 2008, p. 82-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anti-allergic inflammatory effects of hepatocyte growth factor.
AU - Ito, Wataru
AU - Takeda, Masahide
AU - Tanabe, Masako
AU - Kihara, Junko
AU - Kato, Hikari
AU - Chiba, Takahito
AU - Yamaguchi, Kazutoshi
AU - Ueki, Shigeharu
AU - Kanehiro, Arihiko
AU - Kayaba, Hiroyuki
AU - Chihara, Junichi
PY - 2008
Y1 - 2008
N2 - Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-beta in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions.
AB - Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-beta in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions.
UR - http://www.scopus.com/inward/record.url?scp=48849103103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48849103103&partnerID=8YFLogxK
U2 - 10.1159/000126067
DO - 10.1159/000126067
M3 - Article
VL - 146 Suppl 1
SP - 82
EP - 87
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
ER -