Anti-aging effects of co-enzyme Q10 on periodontal tissues

T. Yoneda, T. Tomofuji, D. Ekuni, T. Azuma, Y. Endo, K. Kasuyama, T. Machida, M. Morita

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form of co-enzyme Q10 (rCoQ10) suppress oxidative stress, which may contribute to the prevention of age-related inflammatory reactions. We examined the effects of topically applied rCoQ10 on periodontal inflammatory reactions in a rat aging model. Male Fischer 344 rats, 2 (n = 6) and 4 mos (n = 18) of age, were used. All of the two-month-old rats and 6 of the four-month-old rats were sacrificed and 12 remaining four-month-old rats received topically applied ointment with or without 1% rCoQ10 on the gingival surface until they reached 6 mos of age. The rats showed an age-dependent increase in circulating oxidative stress. RCoQ10 decreased oxidative DNA damage and tartrate-resistant acid-phosphatase-positive osteoclasts in the periodontal tissue at 6 mos of age as compared with the control. The same conditions lowered gene expression of caspase-1 and interleukin-1β in the periodontal tissue. Furthermore, Nod-like receptor protein 3 inflammasomes were less activated in periodontal tissues from rCoQ10-treated rats as compared with the control rats. Our results suggest that rCoQ10 suppresses age-related inflammatory reactions and osteoclast differentiation by inhibiting oxidative stress.

Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalJournal of dental research
Volume92
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • aging
  • coenzyme Q10
  • inflammasomes
  • oxidative stress
  • periodontium
  • preclinical drug evaluation

ASJC Scopus subject areas

  • Dentistry(all)

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