Anti-ageing effects of dentifrices containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) on gingival collagen degradation in rats

Koichiro Irie, Takaaki Tomofuji, Daisuke Ekuni, Yasumasa Endo, Kenta Kasuyama, Tetsuji Azuma, Naofumi Tamaki, Toshiki Yoneda, Manabu Morita

Research output: Contribution to journalArticle

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Abstract

Objective Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) to the gingival surface on gingival collagen degradation in rats. Design Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina® (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months. Results In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p <0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p <0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months. Conclusion These findings indicate that Tomarina ® might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalArchives of Oral Biology
Volume59
Issue number1
DOIs
Publication statusPublished - 2014

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Dentifrices
Anti-Inflammatory Agents
Collagen
Anti-Bacterial Agents
Control Groups
Oxidative Stress
Serum

Keywords

  • Ageing
  • Anti-oxidants
  • Dentifrice
  • Gingival collagen
  • Oxidative stress

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Cell Biology
  • Dentistry(all)

Cite this

Anti-ageing effects of dentifrices containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) on gingival collagen degradation in rats. / Irie, Koichiro; Tomofuji, Takaaki; Ekuni, Daisuke; Endo, Yasumasa; Kasuyama, Kenta; Azuma, Tetsuji; Tamaki, Naofumi; Yoneda, Toshiki; Morita, Manabu.

In: Archives of Oral Biology, Vol. 59, No. 1, 2014, p. 60-65.

Research output: Contribution to journalArticle

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abstract = "Objective Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina{\circledR}) to the gingival surface on gingival collagen degradation in rats. Design Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina{\circledR} (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months. Results In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p <0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p <0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months. Conclusion These findings indicate that Tomarina {\circledR} might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model.",
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AU - Ekuni, Daisuke

AU - Endo, Yasumasa

AU - Kasuyama, Kenta

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AU - Tamaki, Naofumi

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AU - Morita, Manabu

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AB - Objective Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) to the gingival surface on gingival collagen degradation in rats. Design Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina® (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months. Results In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p <0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p <0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months. Conclusion These findings indicate that Tomarina ® might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model.

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