Abstract
The aim of this study was to reveal the clinical features of anterior urethral recurrence in patients with superficial bladder cancer, and to determine the appropriate treatment. Three hundred and three patients with superficial bladder cancer, who were newly diagnosed and initially treated conservatively in our hospital between 1965 and 1990, were followed for at least 5 years and their clinical outcomes were analyzed. Clinical factors, including anterior urethral recurrence, were evaluated statistically regarding tumor progression. Eight patients (2.6%) had anterior urethral recurrence following superficial bladder cancer. Twenty-four patients (7.9%) had tumor progression and 149 (49.2%) had tumor recurrence. In a multivariate analysis using a logistic model, anterior urethral recurrence was the most important factor, followed by histological grade. Four of 5 patients who were treated for anterior urethral recurrent tumors by transurethral resection showed progression and died of the cancer within one year. Two of the remaining three patients who underwent radical cysto-urethrectomy at the time of anterior urethral recurrence survived. Anterior urethral recurrence following superficial bladder cancer is a predictor for rapid subsequent malignant progression. Once there is anterior urethral recurrence, radical intensive therapy, including radical cysto-urethrectomy, should be carried out immediately.
| Original language | English |
|---|---|
| Pages (from-to) | 293-297 |
| Number of pages | 5 |
| Journal | Acta Medica Okayama |
| Volume | 57 |
| Issue number | 6 |
| Publication status | Published - Dec 2003 |
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Keywords
- Anterior urethral recurrence
- Predictor
- Prognosis
- Superficial bladder cancer
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Anterior Urethral Recurrence of Superficial Bladder Cancer : Its Clinical Significance. / Saika, Takashi; Tsushima, Tomoyasu; Nasu, Yasutomo; Arata, Ryoji; Kaku, Haruki; Akebi, Naoki; Kusaka, Nobuyuki; Kumon, Hiromi.
In: Acta Medica Okayama, Vol. 57, No. 6, 12.2003, p. 293-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anterior Urethral Recurrence of Superficial Bladder Cancer
T2 - Its Clinical Significance
AU - Saika, Takashi
AU - Tsushima, Tomoyasu
AU - Nasu, Yasutomo
AU - Arata, Ryoji
AU - Kaku, Haruki
AU - Akebi, Naoki
AU - Kusaka, Nobuyuki
AU - Kumon, Hiromi
PY - 2003/12
Y1 - 2003/12
N2 - The aim of this study was to reveal the clinical features of anterior urethral recurrence in patients with superficial bladder cancer, and to determine the appropriate treatment. Three hundred and three patients with superficial bladder cancer, who were newly diagnosed and initially treated conservatively in our hospital between 1965 and 1990, were followed for at least 5 years and their clinical outcomes were analyzed. Clinical factors, including anterior urethral recurrence, were evaluated statistically regarding tumor progression. Eight patients (2.6%) had anterior urethral recurrence following superficial bladder cancer. Twenty-four patients (7.9%) had tumor progression and 149 (49.2%) had tumor recurrence. In a multivariate analysis using a logistic model, anterior urethral recurrence was the most important factor, followed by histological grade. Four of 5 patients who were treated for anterior urethral recurrent tumors by transurethral resection showed progression and died of the cancer within one year. Two of the remaining three patients who underwent radical cysto-urethrectomy at the time of anterior urethral recurrence survived. Anterior urethral recurrence following superficial bladder cancer is a predictor for rapid subsequent malignant progression. Once there is anterior urethral recurrence, radical intensive therapy, including radical cysto-urethrectomy, should be carried out immediately.
AB - The aim of this study was to reveal the clinical features of anterior urethral recurrence in patients with superficial bladder cancer, and to determine the appropriate treatment. Three hundred and three patients with superficial bladder cancer, who were newly diagnosed and initially treated conservatively in our hospital between 1965 and 1990, were followed for at least 5 years and their clinical outcomes were analyzed. Clinical factors, including anterior urethral recurrence, were evaluated statistically regarding tumor progression. Eight patients (2.6%) had anterior urethral recurrence following superficial bladder cancer. Twenty-four patients (7.9%) had tumor progression and 149 (49.2%) had tumor recurrence. In a multivariate analysis using a logistic model, anterior urethral recurrence was the most important factor, followed by histological grade. Four of 5 patients who were treated for anterior urethral recurrent tumors by transurethral resection showed progression and died of the cancer within one year. Two of the remaining three patients who underwent radical cysto-urethrectomy at the time of anterior urethral recurrence survived. Anterior urethral recurrence following superficial bladder cancer is a predictor for rapid subsequent malignant progression. Once there is anterior urethral recurrence, radical intensive therapy, including radical cysto-urethrectomy, should be carried out immediately.
KW - Anterior urethral recurrence
KW - Predictor
KW - Prognosis
KW - Superficial bladder cancer
UR - http://www.scopus.com/inward/record.url?scp=0942300579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0942300579&partnerID=8YFLogxK
M3 - Article
VL - 57
SP - 293
EP - 297
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 6
ER -