Annexins I and IV inhibit Staphylococcus aureus attachment to human macrophages

Mari Gotoh, Yukiko Takamoto, Kahori Kurosaka, Junko Masuda, Michiru Ida, Ayano Satoh, Eiji Takayama, Kyoko Kojima-Aikawa, Yoshiro Kobayashi, Isamu Matsumoto

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17 Citations (Scopus)

Abstract

Annexins are a family of proteins that bind to phospholipids and carbohydrates in a calcium-dependent manner. They are present in a variety of body fluids. Previous studies have shown that annexins have anti-inflammatory activities for lipid A of Gram-negative bacteria. The present study investigated the effect of annexins on interaction between Gram-positive bacteria and immune cells such as macrophages. Annexins I and IV bound to lipoteichoic acids which are surface molecules on Gram-positive bacteria. Binding of annexins I and IV to whole Staphylococcus aureus (S. aureus) were observed and these bindings were inhibited by lipoteichoic acid from S. aureus. Moreover, annexins I and IV suppressed the attachment of S. aureus to phorbol 12-myristate 13-acetate-treated THP-1 cells (human macrophages). These results suggest that annexins I and IV have ligand specificities toward foreign substances, and that the annexins might have some anti-inflammatory property for Gram-positive bacteria.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalImmunology Letters
Volume98
Issue number2
DOIs
Publication statusPublished - May 15 2005
Externally publishedYes

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Keywords

  • Annexins
  • Anti-inflammatory
  • Gram-positive bacteria
  • Lipoteichoic acid

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Gotoh, M., Takamoto, Y., Kurosaka, K., Masuda, J., Ida, M., Satoh, A., Takayama, E., Kojima-Aikawa, K., Kobayashi, Y., & Matsumoto, I. (2005). Annexins I and IV inhibit Staphylococcus aureus attachment to human macrophages. Immunology Letters, 98(2), 297-302. https://doi.org/10.1016/j.imlet.2004.12.004