Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors

Xiaoxiao Pan, Anja Lührmann, Ayano Satoh, Michelle A. Laskowski-Arce, Craig R. Roy

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalScience
Volume320
Issue number5883
DOIs
Publication statusPublished - Jun 20 2008
Externally publishedYes

Fingerprint

Ankyrin Repeat
Legionella pneumophila
Eukaryotic Cells
Coxiella burnetii
Microtubule Proteins
Proteins
Bacterial Proteins
Endosomes
Vacuoles
Bacterial Infections
Macrophages
Bacteria
Infection

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Pan, X., Lührmann, A., Satoh, A., Laskowski-Arce, M. A., & Roy, C. R. (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science, 320(5883), 1651-1654. https://doi.org/10.1126/science.1158160

Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. / Pan, Xiaoxiao; Lührmann, Anja; Satoh, Ayano; Laskowski-Arce, Michelle A.; Roy, Craig R.

In: Science, Vol. 320, No. 5883, 20.06.2008, p. 1651-1654.

Research output: Contribution to journalArticle

Pan, X, Lührmann, A, Satoh, A, Laskowski-Arce, MA & Roy, CR 2008, 'Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors', Science, vol. 320, no. 5883, pp. 1651-1654. https://doi.org/10.1126/science.1158160
Pan, Xiaoxiao ; Lührmann, Anja ; Satoh, Ayano ; Laskowski-Arce, Michelle A. ; Roy, Craig R. / Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. In: Science. 2008 ; Vol. 320, No. 5883. pp. 1651-1654.
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