Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors

Xiaoxiao Pan, Anja Lührmann, Ayano Satoh, Michelle A. Laskowski-Arce, Craig R. Roy

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalScience
Volume320
Issue number5883
DOIs
Publication statusPublished - Jun 20 2008

ASJC Scopus subject areas

  • General

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    Pan, X., Lührmann, A., Satoh, A., Laskowski-Arce, M. A., & Roy, C. R. (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science, 320(5883), 1651-1654. https://doi.org/10.1126/science.1158160