Anisaldehyde, a melanogenesis potentiator

Teruhiko Nitoda, Maria D. Fan, Isao Kubo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Issue number1-2
Publication statusPublished - 2007
Externally publishedYes


  • Anisaldehyde
  • B16-F10 melanoma cells
  • Tyrosinase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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