Abstract
Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.
Original language | English |
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Pages (from-to) | 143-149 |
Number of pages | 7 |
Journal | Zeitschrift fur Naturforschung - Section C Journal of Biosciences |
Volume | 62 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
Keywords
- Anisaldehyde
- B16-F10 melanoma cells
- Tyrosinase
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)