TY - JOUR
T1 - Anisaldehyde, a melanogenesis potentiator
AU - Nitoda, Teruhiko
AU - Fan, Maria D.
AU - Kubo, Isao
N1 - Funding Information:
T. N. thanks Japan Society for the Promotion of Science for financial support during his study at UC Berkeley.
PY - 2007
Y1 - 2007
N2 - Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.
AB - Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.
KW - Anisaldehyde
KW - B16-F10 melanoma cells
KW - Tyrosinase
UR - http://www.scopus.com/inward/record.url?scp=34248357172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248357172&partnerID=8YFLogxK
U2 - 10.1515/znc-2007-1-224
DO - 10.1515/znc-2007-1-224
M3 - Article
C2 - 17425120
AN - SCOPUS:34248357172
VL - 62
SP - 143
EP - 149
JO - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
JF - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
SN - 0939-5075
IS - 1-2
ER -