Anisaldehyde, a melanogenesis potentiator

Teruhiko Nitoda; Maria D. Fan; Isao Kubo

doi:10.1515/znc-2007-1-224

Anisaldehyde, a melanogenesis potentiator

Teruhiko Nitoda, Maria D. Fan, Isao Kubo

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.

Original language	English
Pages (from-to)	143-149
Number of pages	7
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	62
Issue number	1-2
DOIs	https://doi.org/10.1515/znc-2007-1-224
Publication status	Published - 2007
Externally published	Yes

Keywords

Anisaldehyde
B16-F10 melanoma cells
Tyrosinase

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Anisaldehyde, a melanogenesis potentiator",

abstract = "Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.",

keywords = "Anisaldehyde, B16-F10 melanoma cells, Tyrosinase",

author = "Teruhiko Nitoda and Fan, {Maria D.} and Isao Kubo",

note = "Funding Information: T. N. thanks Japan Society for the Promotion of Science for financial support during his study at UC Berkeley. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2007",

doi = "10.1515/znc-2007-1-224",

language = "English",

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pages = "143--149",

journal = "Zeitschrift fur Naturforschung. Section C: Biosciences",

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T1 - Anisaldehyde, a melanogenesis potentiator

AU - Nitoda, Teruhiko

AU - Fan, Maria D.

AU - Kubo, Isao

PY - 2007

Y1 - 2007

N2 - Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.

AB - Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations showed the deposition of melanin pigments. Anisaldehyde was also examined against cultured human A375 melanoma cells.

KW - Anisaldehyde

KW - B16-F10 melanoma cells

KW - Tyrosinase

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JO - Zeitschrift fur Naturforschung. Section C: Biosciences

JF - Zeitschrift fur Naturforschung. Section C: Biosciences

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ER -

Anisaldehyde, a melanogenesis potentiator

Abstract

Keywords

ASJC Scopus subject areas

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