Animal models for Parkinson’s disease research: Trends in the 2000s

Research output: Contribution to journalReview article

Abstract

Parkinson’s disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.

Original languageEnglish
Article number5402
JournalInternational journal of molecular sciences
Volume20
Issue number21
DOIs
Publication statusPublished - Nov 1 2019

Fingerprint

Parkinson disease
animal models
Parkinson Disease
Animals
Animal Models
trends
Research
Neurodegenerative diseases
Genetic Models
Neurotoxins
Movement Disorders
pathology
Pathology
Neurodegenerative Diseases
therapy
disorders
Technology

Keywords

  • 1-methyl-4-phenyl-1
  • 2
  • 3
  • 6-hydroxydopamine
  • 6-tetrahydropyridine
  • Animal model
  • DJ-1
  • Neurotoxin
  • Parkin
  • Parkinson’s disease
  • Pesticide
  • PINK1
  • α-synuclein

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Animal models for Parkinson’s disease research : Trends in the 2000s. / Kin, Kyohei; Yasuhara, Takao; Kameda, Masahiro; Date, Isao.

In: International journal of molecular sciences, Vol. 20, No. 21, 5402, 01.11.2019.

Research output: Contribution to journalReview article

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