Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis

Hiroyuki Murakami, Masanori Makita, Tatsunori Ishikawa, Takanori Yoshioka, Keina Nagakita, Yoko Shinno, Tadashi Yoshino, Yoshinobu Maeda, Kazutaka Sunami

Research output: Contribution to journalArticlepeer-review

Abstract

A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.

Original languageEnglish
Pages (from-to)2655-2660
Number of pages6
JournalInternal Medicine
Volume61
Issue number17
DOIs
Publication statusPublished - 2022

Keywords

  • angioimmunoblastic T-cell lymphoma
  • methotrexate
  • MTX-associated lymphoproliferative disorder
  • plasmacytosis

ASJC Scopus subject areas

  • Internal Medicine

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