Abstract
Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p
| Original language | English |
|---|---|
| Pages (from-to) | 315-319 |
| Number of pages | 5 |
| Journal | European Journal of Medical Research |
| Volume | 14 |
| Issue number | 7 |
| Publication status | Published - Jul 22 2009 |
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Keywords
- Angiogenic squamous dysplasia
- CD105
- CD31, CD34
- Immunohistochemistry
- Oral precursor lesions
ASJC Scopus subject areas
- Medicine(all)
Cite this
Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions. / Siar, C. H.; Oo, V. P A; Nagatsuka, Hitoshi; Nakano, Keisuke; Ng, K. H.; Kawakami, T.
In: European Journal of Medical Research, Vol. 14, No. 7, 22.07.2009, p. 315-319.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
AU - Siar, C. H.
AU - Oo, V. P A
AU - Nagatsuka, Hitoshi
AU - Nakano, Keisuke
AU - Ng, K. H.
AU - Kawakami, T.
PY - 2009/7/22
Y1 - 2009/7/22
N2 - Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p
AB - Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p
KW - Angiogenic squamous dysplasia
KW - CD105
KW - CD31, CD34
KW - Immunohistochemistry
KW - Oral precursor lesions
UR - http://www.scopus.com/inward/record.url?scp=70149122204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70149122204&partnerID=8YFLogxK
M3 - Article
C2 - 19661015
AN - SCOPUS:70149122204
VL - 14
SP - 315
EP - 319
JO - European Journal of Medical Research
JF - European Journal of Medical Research
SN - 0949-2321
IS - 7
ER -