Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions

C. H. Siar, V. P A Oo, Hitoshi Nagatsuka, Keisuke Nakano, K. H. Ng, T. Kawakami

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalEuropean Journal of Medical Research
Volume14
Issue number7
Publication statusPublished - Jul 22 2009

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Epithelium
Mouth Mucosa
Microvessels
Carcinoma in Situ
Staining and Labeling

Keywords

  • Angiogenic squamous dysplasia
  • CD105
  • CD31, CD34
  • Immunohistochemistry
  • Oral precursor lesions

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions. / Siar, C. H.; Oo, V. P A; Nagatsuka, Hitoshi; Nakano, Keisuke; Ng, K. H.; Kawakami, T.

In: European Journal of Medical Research, Vol. 14, No. 7, 22.07.2009, p. 315-319.

Research output: Contribution to journalArticle

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AU - Oo, V. P A

AU - Nagatsuka, Hitoshi

AU - Nakano, Keisuke

AU - Ng, K. H.

AU - Kawakami, T.

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