Angioarchitecture of primary oral malignant melanomas

You Jin Lee, Noriyuki Nagai, Chong Huat Siar, Keisuke Nakano, Hitoshi Nagatsuka, Hidetsugu Tsujigiwa, Cheng Hsiung Roan, Mehmet Gunduz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Angiogenesis is an essential process in the progression of malignant tumors. However, little is known of the angioarchitecture in primary oral malignant melanoma. We sought to determine this by the use of periodic acid-Schiff (PAS) stain, endothelial markers (CD34, CD105) and laminin, and by transmission electron microscopy in two cases. The results demonstrated that endothelium-lined vessels dominated the tumor microvasculature and these stained positively for PAS, laminin, and endothelial markers. Mosaic and tumor-lined vessels were infrequently encountered. Most PAS-positive patterned networks and loops ultrastructurally represented intratumor microhemorrhages that probably arose secondary to tumor vessel leakiness. Vascular channels of the vasculogenic mimicry type were rare. They stained for laminin but not for endothelial markers.

Original languageEnglish
Pages (from-to)1555-1562
Number of pages8
JournalJournal of Histochemistry and Cytochemistry
Volume50
Issue number11
Publication statusPublished - Nov 2002

Fingerprint

Periodic Acid
Melanoma
Laminin
Neoplasms
Microvessels
Transmission Electron Microscopy
Endothelium
Blood Vessels
Coloring Agents

Keywords

  • Co-opted vessels
  • Immunohistochemistry
  • Intracellular channels
  • Mosaic vessels
  • Oral malignant melanoma
  • Periodic acid-Schiff stain
  • Transmission electron microscopy
  • Tumor microvasculature
  • Vascular channels

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Lee, Y. J., Nagai, N., Siar, C. H., Nakano, K., Nagatsuka, H., Tsujigiwa, H., ... Gunduz, M. (2002). Angioarchitecture of primary oral malignant melanomas. Journal of Histochemistry and Cytochemistry, 50(11), 1555-1562.

Angioarchitecture of primary oral malignant melanomas. / Lee, You Jin; Nagai, Noriyuki; Siar, Chong Huat; Nakano, Keisuke; Nagatsuka, Hitoshi; Tsujigiwa, Hidetsugu; Roan, Cheng Hsiung; Gunduz, Mehmet.

In: Journal of Histochemistry and Cytochemistry, Vol. 50, No. 11, 11.2002, p. 1555-1562.

Research output: Contribution to journalArticle

Lee, YJ, Nagai, N, Siar, CH, Nakano, K, Nagatsuka, H, Tsujigiwa, H, Roan, CH & Gunduz, M 2002, 'Angioarchitecture of primary oral malignant melanomas', Journal of Histochemistry and Cytochemistry, vol. 50, no. 11, pp. 1555-1562.
Lee, You Jin ; Nagai, Noriyuki ; Siar, Chong Huat ; Nakano, Keisuke ; Nagatsuka, Hitoshi ; Tsujigiwa, Hidetsugu ; Roan, Cheng Hsiung ; Gunduz, Mehmet. / Angioarchitecture of primary oral malignant melanomas. In: Journal of Histochemistry and Cytochemistry. 2002 ; Vol. 50, No. 11. pp. 1555-1562.
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