Androgen action in the brain and spinal cord for the regulation of male sexual behaviors

Ken ichi Matsuda, Hirotaka Sakamoto, Mitsuhiro Kawata

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Circulating levels of androgens determine the sexual differentiation of the brain and spinal cord at a critical period. Although estradiol, which is converted from testosterone by aromatase action, can explain the cytological basis for the sexual dimorphism, androgen has its own regulatory mechanism to promote male-specific behavior through receptors. The central nervous system (CNS) employs a sex-specific neuronal network involving peptides and steroids for the expression of the sexual phenotype. Elucidation of the molecular mechanism along with the neuroanatomical background should guide the development of novel pharmacotherapeutics for sexual behavior dysfunction.

Original languageEnglish
Pages (from-to)747-751
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume8
Issue number6
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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