Andirolides H-P from the flower of andiroba (Carapa guianensis, Meliaceae)

Yuji Tanaka, Asami Sakamoto, Takanobu Inoue, Takeshi Yamada, Takashi Kikuchi, Tetsuya Kajimoto, Osamu Muraoka, Akira Sato, Yusuke Wataya, Hye Sook Kim, Reiko Tanaka

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Abstract

Three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides H (1), I (2), J (3), K (4), L (5), M (6), N (7), O (8), and P (9) were isolated from an oil of the flower of Carapa guianensis Aublet (Meliaceae). Their structures including the absolute configurations were determined by means of the NMR and CD spectra as well as FABMS. Andirolide H (1) showed antimalarial activity against Plasmodium falciparum in vitro.

Original languageEnglish
Pages (from-to)3669-3677
Number of pages9
JournalTetrahedron
Volume68
Issue number18
DOIs
Publication statusPublished - May 6 2012

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Tanaka, Y., Sakamoto, A., Inoue, T., Yamada, T., Kikuchi, T., Kajimoto, T., Muraoka, O., Sato, A., Wataya, Y., Kim, H. S., & Tanaka, R. (2012). Andirolides H-P from the flower of andiroba (Carapa guianensis, Meliaceae). Tetrahedron, 68(18), 3669-3677. https://doi.org/10.1016/j.tet.2011.12.076