ANCA-associated systemic vasculitis in Japan: Clinical features and prognostic changes

Kunihiro Yamagata, Joichi Usui, Chie Saito, Naoto Yamaguchi, Kouichi Hirayama, Kaori Mase, Masaki Kobayashi, Akio Koyama, Hitoshi Sugiyama, Kosaku Nitta, Takashi Wada, Eri Muso, Yoshihiro Arimura, Hirofumi Makino, Seiichi Matsuo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: This study was conducted to standardize treatment and determine patient and renal outcome in Japanese anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis/rapidly progressive glomerulonephritis (AAV/RPGN) patients, because the prognosis of AAV/RPGN patients in Japan had been poor compared with that of other countries. Methods: The participants in this retrospective cohort study were 824 ANCA-positive RPGN patients, 705 of whom were only myeloperoxidase (MPO)-ANCA positive. Results: Among the early-years cohort (group A; cases diagnosed between 1988 and 1998), patients frequently died due to opportunistic infection. Therefore, we recommended a reduced dose of prednisolone (oral prednisolone dose

Original languageEnglish
Pages (from-to)580-588
Number of pages9
JournalClinical and Experimental Nephrology
Volume16
Issue number4
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

Fingerprint

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Systemic Vasculitis
Japan
Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Prednisolone
Opportunistic Infections
Peroxidase
Cohort Studies
Retrospective Studies
Kidney

Keywords

  • Anti-neutrophil cytoplasmic auto-antibody (ANCA)
  • Immunosuppression
  • Prognosis changes
  • Rapidly progressive glomerulonephritis (RPGN)
  • Vasculitis

ASJC Scopus subject areas

  • Nephrology
  • Physiology
  • Physiology (medical)

Cite this

Yamagata, K., Usui, J., Saito, C., Yamaguchi, N., Hirayama, K., Mase, K., ... Matsuo, S. (2012). ANCA-associated systemic vasculitis in Japan: Clinical features and prognostic changes. Clinical and Experimental Nephrology, 16(4), 580-588. https://doi.org/10.1007/s10157-012-0598-2

ANCA-associated systemic vasculitis in Japan : Clinical features and prognostic changes. / Yamagata, Kunihiro; Usui, Joichi; Saito, Chie; Yamaguchi, Naoto; Hirayama, Kouichi; Mase, Kaori; Kobayashi, Masaki; Koyama, Akio; Sugiyama, Hitoshi; Nitta, Kosaku; Wada, Takashi; Muso, Eri; Arimura, Yoshihiro; Makino, Hirofumi; Matsuo, Seiichi.

In: Clinical and Experimental Nephrology, Vol. 16, No. 4, 08.2012, p. 580-588.

Research output: Contribution to journalArticle

Yamagata, K, Usui, J, Saito, C, Yamaguchi, N, Hirayama, K, Mase, K, Kobayashi, M, Koyama, A, Sugiyama, H, Nitta, K, Wada, T, Muso, E, Arimura, Y, Makino, H & Matsuo, S 2012, 'ANCA-associated systemic vasculitis in Japan: Clinical features and prognostic changes', Clinical and Experimental Nephrology, vol. 16, no. 4, pp. 580-588. https://doi.org/10.1007/s10157-012-0598-2
Yamagata, Kunihiro ; Usui, Joichi ; Saito, Chie ; Yamaguchi, Naoto ; Hirayama, Kouichi ; Mase, Kaori ; Kobayashi, Masaki ; Koyama, Akio ; Sugiyama, Hitoshi ; Nitta, Kosaku ; Wada, Takashi ; Muso, Eri ; Arimura, Yoshihiro ; Makino, Hirofumi ; Matsuo, Seiichi. / ANCA-associated systemic vasculitis in Japan : Clinical features and prognostic changes. In: Clinical and Experimental Nephrology. 2012 ; Vol. 16, No. 4. pp. 580-588.
@article{294f83ea9d28412d93bb2f6df5769b68,
title = "ANCA-associated systemic vasculitis in Japan: Clinical features and prognostic changes",
abstract = "Background: This study was conducted to standardize treatment and determine patient and renal outcome in Japanese anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis/rapidly progressive glomerulonephritis (AAV/RPGN) patients, because the prognosis of AAV/RPGN patients in Japan had been poor compared with that of other countries. Methods: The participants in this retrospective cohort study were 824 ANCA-positive RPGN patients, 705 of whom were only myeloperoxidase (MPO)-ANCA positive. Results: Among the early-years cohort (group A; cases diagnosed between 1988 and 1998), patients frequently died due to opportunistic infection. Therefore, we recommended a reduced dose of prednisolone (oral prednisolone dose",
keywords = "Anti-neutrophil cytoplasmic auto-antibody (ANCA), Immunosuppression, Prognosis changes, Rapidly progressive glomerulonephritis (RPGN), Vasculitis",
author = "Kunihiro Yamagata and Joichi Usui and Chie Saito and Naoto Yamaguchi and Kouichi Hirayama and Kaori Mase and Masaki Kobayashi and Akio Koyama and Hitoshi Sugiyama and Kosaku Nitta and Takashi Wada and Eri Muso and Yoshihiro Arimura and Hirofumi Makino and Seiichi Matsuo",
year = "2012",
month = "8",
doi = "10.1007/s10157-012-0598-2",
language = "English",
volume = "16",
pages = "580--588",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - ANCA-associated systemic vasculitis in Japan

T2 - Clinical features and prognostic changes

AU - Yamagata, Kunihiro

AU - Usui, Joichi

AU - Saito, Chie

AU - Yamaguchi, Naoto

AU - Hirayama, Kouichi

AU - Mase, Kaori

AU - Kobayashi, Masaki

AU - Koyama, Akio

AU - Sugiyama, Hitoshi

AU - Nitta, Kosaku

AU - Wada, Takashi

AU - Muso, Eri

AU - Arimura, Yoshihiro

AU - Makino, Hirofumi

AU - Matsuo, Seiichi

PY - 2012/8

Y1 - 2012/8

N2 - Background: This study was conducted to standardize treatment and determine patient and renal outcome in Japanese anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis/rapidly progressive glomerulonephritis (AAV/RPGN) patients, because the prognosis of AAV/RPGN patients in Japan had been poor compared with that of other countries. Methods: The participants in this retrospective cohort study were 824 ANCA-positive RPGN patients, 705 of whom were only myeloperoxidase (MPO)-ANCA positive. Results: Among the early-years cohort (group A; cases diagnosed between 1988 and 1998), patients frequently died due to opportunistic infection. Therefore, we recommended a reduced dose of prednisolone (oral prednisolone dose

AB - Background: This study was conducted to standardize treatment and determine patient and renal outcome in Japanese anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis/rapidly progressive glomerulonephritis (AAV/RPGN) patients, because the prognosis of AAV/RPGN patients in Japan had been poor compared with that of other countries. Methods: The participants in this retrospective cohort study were 824 ANCA-positive RPGN patients, 705 of whom were only myeloperoxidase (MPO)-ANCA positive. Results: Among the early-years cohort (group A; cases diagnosed between 1988 and 1998), patients frequently died due to opportunistic infection. Therefore, we recommended a reduced dose of prednisolone (oral prednisolone dose

KW - Anti-neutrophil cytoplasmic auto-antibody (ANCA)

KW - Immunosuppression

KW - Prognosis changes

KW - Rapidly progressive glomerulonephritis (RPGN)

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=84865110816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865110816&partnerID=8YFLogxK

U2 - 10.1007/s10157-012-0598-2

DO - 10.1007/s10157-012-0598-2

M3 - Article

C2 - 22350463

AN - SCOPUS:84865110816

VL - 16

SP - 580

EP - 588

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 4

ER -