Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study

Chieko Kudo, Wee Soo Shin, Masato Minabe, Kazuo Harai, Kai Kato, Hiroaki Seino, Eiji Goke, Nobuhiro Sasaki, Takemasa Fujino, Nobuichi Kuribayashi, Youko Onuki Pearce, Masato Taira, Hiroshi Maeda, Shogo Takashiba

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of “chronic inflammation”. Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between periodontal disease and atherosclerosis under collaborative medical and dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed. There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis. Plasma IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for atherosclerosis related to periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.

Original languageEnglish
Pages (from-to)314-321
Number of pages8
JournalOdontology
Volume103
Issue number3
DOIs
Publication statusPublished - Aug 14 2014

Fingerprint

Periodontal Diseases
Observational Studies
Atherosclerosis
Porphyromonas gingivalis
Immunoglobulin G
Dental Care
LDL Cholesterol
Life Style
Biomarkers
Dental Clinics
Infection
Referral and Consultation
Cross-Sectional Studies
Inflammation
Bacteria
Antibodies

Keywords

  • Atherosclerosis
  • Collaborative medical and dental care
  • Low-density lipoprotein cholesterol
  • Periodontal disease
  • Plasma IgG titer to Porphyromonas gingivalis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system : a cross-sectional observational pilot study. / Kudo, Chieko; Shin, Wee Soo; Minabe, Masato; Harai, Kazuo; Kato, Kai; Seino, Hiroaki; Goke, Eiji; Sasaki, Nobuhiro; Fujino, Takemasa; Kuribayashi, Nobuichi; Pearce, Youko Onuki; Taira, Masato; Maeda, Hiroshi; Takashiba, Shogo.

In: Odontology, Vol. 103, No. 3, 14.08.2014, p. 314-321.

Research output: Contribution to journalArticle

Kudo, C, Shin, WS, Minabe, M, Harai, K, Kato, K, Seino, H, Goke, E, Sasaki, N, Fujino, T, Kuribayashi, N, Pearce, YO, Taira, M, Maeda, H & Takashiba, S 2014, 'Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study', Odontology, vol. 103, no. 3, pp. 314-321. https://doi.org/10.1007/s10266-014-0172-3
Kudo, Chieko ; Shin, Wee Soo ; Minabe, Masato ; Harai, Kazuo ; Kato, Kai ; Seino, Hiroaki ; Goke, Eiji ; Sasaki, Nobuhiro ; Fujino, Takemasa ; Kuribayashi, Nobuichi ; Pearce, Youko Onuki ; Taira, Masato ; Maeda, Hiroshi ; Takashiba, Shogo. / Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system : a cross-sectional observational pilot study. In: Odontology. 2014 ; Vol. 103, No. 3. pp. 314-321.
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