Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor

Naoki Katase, Hitoshi Nagatsuka, Hidetsugu Tsujigiwa, Mehmet Gunduz, Ryo Tamamura, Han Phuu Pwint, Rosario Santos Rivera, Motowo Nakajima, Yoshio Naomoto, Noriyuki Nagai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Keratocystic odontogenic tumor (KCOT), also known as odontogenic keratocyst, is a benign cystic neoplasm, which may be associated with nevoid basal cell carcinoma syndrome (NBCCS) and if it does, will occur as multiple cystic lesions. KCOT is locally destructive despite its bland histological features. However, the neoplastic nature of KCOT is not well established. Heparanase is an endo-d-glucuronidase enzyme that specifically cleaves heparan sulfate (HS) and the increase of its level in tumors promotes invasion, angiogenesis, and metastasis. Methods: To investigate the neoplastic character of KCOT, we studied the localization patterns of heparanase in KCOT, focusing on the differences between sporadic and NBCCS-associated KCOTs, by immunohistochemistry and in situ hybridization. To compare the expression pattern of these cysts with non-tumorous odontogenic developmental cyst, dentigerous cyst was included. Results: All the odontogenic cysts showed positive immunoreaction for heparanase protein in various intensities. The expression pattern of heparanase gene corresponded to that of protein expression. Interestingly, intense gene and protein expressions were observed in KCOT associated with NBCCS compared with sporadic ones and dentigerous cyst. Conclusions: The results implied that heparanase expression may be correlated with the neoplastic properties of KCOT, particularly in NBCCS-associated cases.

Original languageEnglish
Pages (from-to)550-554
Number of pages5
JournalJournal of Oral Pathology and Medicine
Volume36
Issue number9
DOIs
Publication statusPublished - Oct 2007

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Basal Cell Nevus Syndrome
Odontogenic Tumors
Odontogenic Cysts
Dentigerous Cyst
Proteins
Heparitin Sulfate
Glucuronidase
In Situ Hybridization
Cysts
Neoplasms
Immunohistochemistry
heparanase
Neoplasm Metastasis
Gene Expression
Enzymes

Keywords

  • Heparanase
  • Keratocystic odontogenic tumor

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor. / Katase, Naoki; Nagatsuka, Hitoshi; Tsujigiwa, Hidetsugu; Gunduz, Mehmet; Tamamura, Ryo; Pwint, Han Phuu; Rivera, Rosario Santos; Nakajima, Motowo; Naomoto, Yoshio; Nagai, Noriyuki.

In: Journal of Oral Pathology and Medicine, Vol. 36, No. 9, 10.2007, p. 550-554.

Research output: Contribution to journalArticle

Katase, Naoki ; Nagatsuka, Hitoshi ; Tsujigiwa, Hidetsugu ; Gunduz, Mehmet ; Tamamura, Ryo ; Pwint, Han Phuu ; Rivera, Rosario Santos ; Nakajima, Motowo ; Naomoto, Yoshio ; Nagai, Noriyuki. / Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor. In: Journal of Oral Pathology and Medicine. 2007 ; Vol. 36, No. 9. pp. 550-554.
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AU - Tsujigiwa, Hidetsugu

AU - Gunduz, Mehmet

AU - Tamamura, Ryo

AU - Pwint, Han Phuu

AU - Rivera, Rosario Santos

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AU - Naomoto, Yoshio

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