Analysis of stimulants and related compounds by automated on-line in- tube SPME/LC/MS

H. Kataoka, S. Narimatsu, H. L. Lord, J. Pawliszyn

Research output: Contribution to journalArticle

Abstract

A simple and rapid method for the analysis of amphetamines and their 3,4-methylenedioxy derivatives was developed by automated in-tube solid-phase microextraction/liquid chromatography/electrospray ionization mass spectrometry (in-tube SPME/LC/ESI-MS). Optimum In-tube SPME conditions for these drugs were 15 draw/eject cycles of 35 μL of sample in Tris-HCl (pH 8.5) using Omegawax 250 capillary column. The drugs extracted by the capillary column were easily desorbed by mobile phase flow, and carryover was not observed. Using in-tube SPME/LC/ESI-MS with selected ion monitoring, the calibration curves of these drugs were linear in the range of 2-100 ng/mL with correlation coefficients above 0.9985 (n=18), and the detection limits (S/N=3) were 0.4-0.8 ng/mL. This method was successfully applied to the analysis of urine samples without interference peaks and with recoveries above 80%.

Original languageEnglish
Pages (from-to)150-151
Number of pages2
JournalJapanese Journal of Forensic Toxicology
Volume18
Issue number2
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Pharmaceutical Preparations
Amphetamines
Solid Phase Microextraction
Electrospray ionization
Electrospray Ionization Mass Spectrometry
Liquid chromatography
Liquid Chromatography
Calibration
Mass spectrometry
Limit of Detection
Urine
Ions
Derivatives
Recovery
Monitoring
4-sulfophenylmethallyl ether

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology

Cite this

Kataoka, H., Narimatsu, S., Lord, H. L., & Pawliszyn, J. (2000). Analysis of stimulants and related compounds by automated on-line in- tube SPME/LC/MS. Japanese Journal of Forensic Toxicology, 18(2), 150-151.

Analysis of stimulants and related compounds by automated on-line in- tube SPME/LC/MS. / Kataoka, H.; Narimatsu, S.; Lord, H. L.; Pawliszyn, J.

In: Japanese Journal of Forensic Toxicology, Vol. 18, No. 2, 2000, p. 150-151.

Research output: Contribution to journalArticle

Kataoka, H, Narimatsu, S, Lord, HL & Pawliszyn, J 2000, 'Analysis of stimulants and related compounds by automated on-line in- tube SPME/LC/MS', Japanese Journal of Forensic Toxicology, vol. 18, no. 2, pp. 150-151.
Kataoka, H. ; Narimatsu, S. ; Lord, H. L. ; Pawliszyn, J. / Analysis of stimulants and related compounds by automated on-line in- tube SPME/LC/MS. In: Japanese Journal of Forensic Toxicology. 2000 ; Vol. 18, No. 2. pp. 150-151.
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