Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine.

Takako Hasegawa, Michiko Futagami, Hye-Sook Kim, Akira Matsuda, Yusuke Wataya

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

We investigated single nucleotide polymorphisms (SNPs) in uck2 gene encoding metabolic enzyme of 3'-ethynylcytidine (ECyd) which were associated with drug response of ECyd, and the newly synthesized antitumor ribonucleoside analog. We analized that on exon-intron junction and exon region to affect the qualitative alteration of gene product directly in ECyd sensitive and resistant human cancer cell lines. As the results, cSNP and sSNP were detected in exon 4. In the promoter region, 3 SNPs were detected. Our data seem to be able to give an important knowledge, when ECyd is applied clinically.

Original languageEnglish
Title of host publicationNucleic acids research. Supplement (2001)
Pages237-238
Number of pages2
Edition2
Publication statusPublished - 2002

Fingerprint

Uridine Kinase
Single Nucleotide Polymorphism
Exons
Enzymes
Genes
Ribonucleosides
Genetic Promoter Regions
Introns
Cell Line
Pharmaceutical Preparations
1-(3-C-ethynylribopentofuranosyl)cytosine
Neoplasms

Cite this

Hasegawa, T., Futagami, M., Kim, H-S., Matsuda, A., & Wataya, Y. (2002). Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. In Nucleic acids research. Supplement (2001) (2 ed., pp. 237-238)

Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. / Hasegawa, Takako; Futagami, Michiko; Kim, Hye-Sook; Matsuda, Akira; Wataya, Yusuke.

Nucleic acids research. Supplement (2001). 2. ed. 2002. p. 237-238.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hasegawa, T, Futagami, M, Kim, H-S, Matsuda, A & Wataya, Y 2002, Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. in Nucleic acids research. Supplement (2001). 2 edn, pp. 237-238.
Hasegawa T, Futagami M, Kim H-S, Matsuda A, Wataya Y. Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. In Nucleic acids research. Supplement (2001). 2 ed. 2002. p. 237-238
Hasegawa, Takako ; Futagami, Michiko ; Kim, Hye-Sook ; Matsuda, Akira ; Wataya, Yusuke. / Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. Nucleic acids research. Supplement (2001). 2. ed. 2002. pp. 237-238
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