Abstract
We investigated single nucleotide polymorphisms (SNPs) in uck2 gene encoding metabolic enzyme of 3'-ethynylcytidine (ECyd) which were associated with drug response of ECyd, and the newly synthesized antitumor ribonucleoside analog. We analized that on exon-intron junction and exon region to affect the qualitative alteration of gene product directly in ECyd sensitive and resistant human cancer cell lines. As the results, cSNP and sSNP were detected in exon 4. In the promoter region, 3 SNPs were detected. Our data seem to be able to give an important knowledge, when ECyd is applied clinically.
| Original language | English |
|---|---|
| Title of host publication | Nucleic acids research. Supplement (2001) |
| Pages | 237-238 |
| Number of pages | 2 |
| Edition | 2 |
| Publication status | Published - 2002 |
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Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine. / Hasegawa, Takako; Futagami, Michiko; Kim, Hye-Sook; Matsuda, Akira; Wataya, Yusuke.
Nucleic acids research. Supplement (2001). 2. ed. 2002. p. 237-238.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine.
AU - Hasegawa, Takako
AU - Futagami, Michiko
AU - Kim, Hye-Sook
AU - Matsuda, Akira
AU - Wataya, Yusuke
PY - 2002
Y1 - 2002
N2 - We investigated single nucleotide polymorphisms (SNPs) in uck2 gene encoding metabolic enzyme of 3'-ethynylcytidine (ECyd) which were associated with drug response of ECyd, and the newly synthesized antitumor ribonucleoside analog. We analized that on exon-intron junction and exon region to affect the qualitative alteration of gene product directly in ECyd sensitive and resistant human cancer cell lines. As the results, cSNP and sSNP were detected in exon 4. In the promoter region, 3 SNPs were detected. Our data seem to be able to give an important knowledge, when ECyd is applied clinically.
AB - We investigated single nucleotide polymorphisms (SNPs) in uck2 gene encoding metabolic enzyme of 3'-ethynylcytidine (ECyd) which were associated with drug response of ECyd, and the newly synthesized antitumor ribonucleoside analog. We analized that on exon-intron junction and exon region to affect the qualitative alteration of gene product directly in ECyd sensitive and resistant human cancer cell lines. As the results, cSNP and sSNP were detected in exon 4. In the promoter region, 3 SNPs were detected. Our data seem to be able to give an important knowledge, when ECyd is applied clinically.
UR - http://www.scopus.com/inward/record.url?scp=0041317242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041317242&partnerID=8YFLogxK
M3 - Chapter
C2 - 12903193
AN - SCOPUS:0041317242
SP - 237
EP - 238
BT - Nucleic acids research. Supplement (2001)
ER -