Analysis of Prognostic Factors in Pancreatic Metastases: A Multicenter Retrospective Analysis

Takashi Ito, Ryoji Takada, Shunsuke Omoto, Motoyuki Tsuda, Daisuke Masuda, Hironari Kato, Toshihiko Matsumoto, Ichiro Moriyama, Yoshinobu Okabe, Hideyuki Shiomi, Etsuji Ishida, Keiichi Hatamaru, Shinichi Hashimoto, Kiyohito Tanaka, Hirofumi Kawamoto, Akio Yanagisawa, Toshiro Katayama, Shujiro Yazumi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pancreatic metastases (PMs) account for 1% to 2% of pancreatic tumors, and their prognostic significance is poorly defined. We evaluated the incidence and clinical characteristics of primary tumors and defined prognostic factors. Methods This retrospective study of 39 Japanese tertiary referral hospitals (January 2005 to August 2015) analyzed patient and tumor characteristics and survival time. Kaplan-Meier analysis and Cox proportional hazards models were applied to evaluate overall survival and prognostic factors, respectively. Results We enrolled 159 patients with a pathologic diagnosis of PM. The most common primary tumor was renal cell carcinoma (38.4%), followed by lung cancer (24.5%), colorectal cancer (11.3%), and sarcoma (6.3%). Eight patients were lost during follow-up, and 151 patients were included for statistical analysis. Median overall survival was 43.0 months, and the 5-year survival rate was 42.6%. Multivariate analysis identified 3 independent prognostic factors: extrapancreatic metastasis (hazard ratio, 2.13; 95% confidence interval, 1.11-4.07; P = 0.02), tumor-related symptoms at diagnosis (hazard ratio, 5.39; 95% confidence interval, 2.92-9.91; P < 0.001), and pathologic diagnosis of primary tumors (P < 0.001). Conclusions Treatment strategies and prognoses for PMs completely differ according to the primary tumor type. A definitive pathologic diagnosis of PMs is essential for selecting the appropriate treatment.

Original languageEnglish
Pages (from-to)1033-1039
Number of pages7
JournalPancreas
Volume47
Issue number8
DOIs
Publication statusPublished - Sep 1 2018
Externally publishedYes

Keywords

  • multicenter retrospective analysis
  • pancreatic metastasis
  • prognostic factors

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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  • Cite this

    Ito, T., Takada, R., Omoto, S., Tsuda, M., Masuda, D., Kato, H., Matsumoto, T., Moriyama, I., Okabe, Y., Shiomi, H., Ishida, E., Hatamaru, K., Hashimoto, S., Tanaka, K., Kawamoto, H., Yanagisawa, A., Katayama, T., & Yazumi, S. (2018). Analysis of Prognostic Factors in Pancreatic Metastases: A Multicenter Retrospective Analysis. Pancreas, 47(8), 1033-1039. https://doi.org/10.1097/MPA.0000000000001132